Induction of B cell tumor dormancy by anti-idiotypic antibodies

Eitan Yefenof, Louis Picker, Richard H. Scheuermann, Ellen S. Vitetta, Nancy E. Street, Thomas F. Tucker, Jonathan W. Uhr

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Long-term dormancy of murine B-cell lymphomas can be experimentally induced by immunizing the host with the idiotype expressed on the tumor. Interaction of the cells with anti-idiotype antibodies is sufficient to induce and maintain the dormant state. The growth of lymphoma cells interacting with anti-idiotype antibodies is arrested and they undergo dramatic changes in their morphology, cell-cycle status and oncogene expression. Regrowth of a tumor after long-term dormancy results from the emergence of a tumor cell variant that no longer responds to the antibodies with growth inhibition. These data demonstrate the feasibility of reversing a malignant phenotype of cells by specific growth arrest signals and suggest new approaches for therapeutic intervention in cancer.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalCurrent Opinion in Immunology
Volume5
Issue number5
DOIs
StatePublished - 1993
Externally publishedYes

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Anti-Idiotypic Antibodies
B-Lymphocytes
Neoplasms
Growth
B-Cell Lymphoma
Oncogenes
Cell Communication
Lymphoma
Cell Cycle
Phenotype
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Yefenof, E., Picker, L., Scheuermann, R. H., Vitetta, E. S., Street, N. E., Tucker, T. F., & Uhr, J. W. (1993). Induction of B cell tumor dormancy by anti-idiotypic antibodies. Current Opinion in Immunology, 5(5), 740-744. https://doi.org/10.1016/0952-7915(93)90130-K

Induction of B cell tumor dormancy by anti-idiotypic antibodies. / Yefenof, Eitan; Picker, Louis; Scheuermann, Richard H.; Vitetta, Ellen S.; Street, Nancy E.; Tucker, Thomas F.; Uhr, Jonathan W.

In: Current Opinion in Immunology, Vol. 5, No. 5, 1993, p. 740-744.

Research output: Contribution to journalArticle

Yefenof, E, Picker, L, Scheuermann, RH, Vitetta, ES, Street, NE, Tucker, TF & Uhr, JW 1993, 'Induction of B cell tumor dormancy by anti-idiotypic antibodies', Current Opinion in Immunology, vol. 5, no. 5, pp. 740-744. https://doi.org/10.1016/0952-7915(93)90130-K
Yefenof, Eitan ; Picker, Louis ; Scheuermann, Richard H. ; Vitetta, Ellen S. ; Street, Nancy E. ; Tucker, Thomas F. ; Uhr, Jonathan W. / Induction of B cell tumor dormancy by anti-idiotypic antibodies. In: Current Opinion in Immunology. 1993 ; Vol. 5, No. 5. pp. 740-744.
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