Induction of, 5-lactamase and penicillin-binding proteins in escherichia coli by introduction of streptomyces dna

Hisayoshi Nakazawa, Michiko M. Nakano, Hiroshi Ogawara

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction of hybrid plasmids, which were constructed by ligation of pCRl or pMNl vector plasmid and SalI restriction endonuclease cleaved segments of Streptomyces cacaoi chromosome, resulted in the production of new β-lactamase and penicillin-binding protein in Escherichia coli. The, 5-lactamase and penicillin-binding protein were not from S. cacaoi but rather induced by the plasmids. Close relationship was observed between plasmids and penicillin-binding proteins but not with, 5-lactamase.

Original languageEnglish (US)
Pages (from-to)1543-1548
Number of pages6
JournalThe Journal of Antibiotics
Volume36
Issue number11
DOIs
StatePublished - Jan 1983

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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