Induction of β-lactamase and penicillin-binding proteins in Escherichia coli by introduction of Streptomyces DNA

H. Nakazawa, Michiko Nakano, H. Ogawara

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Introduction of hybrid plasmids, which were constructed by ligation of pCR1 or pMN1 vector plasmid and Sa/I restriction endonuclease cleaved segments of Streptomyces cacaoi chromosome, resulted in the production of new β-lactamase and penicillin-binding protein in Escherichia coli. The β-lactamase and penicillin-binding protein were not from S. cacaoi but rather induced by the plasmids. Close relationship was observed between plasmids and penicillin-binding proteins but not with β-lactamase.

Original languageEnglish (US)
Pages (from-to)1543-1548
Number of pages6
JournalJournal of Antibiotics
Issue number11
Publication statusPublished - 1983
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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