Induction-maintenance therapy for HIV-1 infection

Marcel Curlin, Timothy Wilkin, John Mittler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recent clinical trials have renewed interest in treating HIV-1 infection through the use of induction-maintenance regimens, a strategy commonly used for the treatment of TB and certain hematopoeitic malignancies. In these conditions, the common element underlying success has been the ability of induction regimens to reduce therapy-resistant pathogens to levels that can be controlled using a maintenance regimen. The success of recent clinical trials of induction-maintenance therapy for HIV-1 suggests that this concept could have a variety of applications, such as reducing toxicities, reducing treatment costs and improving the treatment of salvage patients. However, current induction-maintenance protocols have not fully capitalized on available quantitative data concerning pharmacokinetics and pharmacodynamics, viral replication dynamics, viral latency and the evolution of drug resistance. In this review, we reason that it should be possible to improve success rates of induction-maintenance and other innovative, therapeutic strategies using mathematical models that account for this information.

Original languageEnglish (US)
Pages (from-to)175-185
Number of pages11
JournalFuture HIV Therapy
Volume2
Issue number2
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

HIV Infections
HIV-1
Maintenance
Clinical Trials
Virus Latency
Salvage Therapy
Therapeutics
Drug Resistance
Health Care Costs
Theoretical Models
Pharmacokinetics
Neoplasms

Keywords

  • AIDS
  • Antiretroviral drugs
  • Drug resistance
  • Drug therapy
  • HIV-1
  • Induction-maintenance
  • Mathematical model

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

Cite this

Induction-maintenance therapy for HIV-1 infection. / Curlin, Marcel; Wilkin, Timothy; Mittler, John.

In: Future HIV Therapy, Vol. 2, No. 2, 2008, p. 175-185.

Research output: Contribution to journalArticle

Curlin, Marcel ; Wilkin, Timothy ; Mittler, John. / Induction-maintenance therapy for HIV-1 infection. In: Future HIV Therapy. 2008 ; Vol. 2, No. 2. pp. 175-185.
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