Induction bortezomib in AL amyloidosis followed by high dose melphalan and autologous stem cell transplantation: A single institution retrospective study

Emma C. Scott, Stephen B. Heitner, William Dibb, Gabrielle Meyers, Stephen D. Smith, Farnoush Abar, Tibor Kovacsovics, Galit Perez-Avraham, Alex Stentz, Rachel Frires, James Dibb, Richard T. Maziarz

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

High dose therapy for light chain amyloidosis (AL) was performed in 31 patients at a single institution. This is a retrospective study, describing the outcomes of patients with and without cardiac involvement, patients not pre-treated as well as those that received induction chemotherapy. Bortezomib is well tolerated and results in higher overall response rates and shorter time to hematologic response.

Introduction/Background: High-dose melphalan (HDM) followed by autologous stem cell transplant (ASCT) for light chain amyloidosis (AL) was performed in 31 patients at Oregon Health and Science University between 2005 and 2012. Fifteen patients had cardiac involvement.

Patients and Methods: Patients received melphalan 200 mg/m2 or doseadjusted HDM (100-140 mg/m2) depending on high risk features. Thirteen patients proceeded directly to ASCT after diagnosis, 12 patients received a bortezomib-containing regimen, and 6 received a variety of other induction regimens.

Results: The day 100 treatment-related mortality was 9.6%. Overall hematologic (ORR) and organ response rates (OR) in the whole cohort after ASCT were 77% and 58%. ORR and OR in the bortezomib pretreated group were 92% and 75% vs. 69% and 54% in the group that received no pretreatment. The median time to maximum hematologic response after ASCT was reduced in the group that received bortezomib induction (3 vs. 14 months). Overall cardiac response rate was 60%; 100% in patients pretreated with bortezomib and 43% in those without induction treatment. With a median follow-up of 2.9 years, the 3-year progression-free and overall survival rates in the entire cohort were 66% and 73% and in those with cardiac involvement, 73% and 80%. Conclusion: We observed that bortezomib-based induction is well tolerated in patients with and without cardiac involvement and suggest that this approach be studied in prospective multi-institutional trials.

Original languageEnglish (US)
Pages (from-to)424-430.e1
JournalClinical Lymphoma, Myeloma and Leukemia
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2014

Keywords

  • Amyloid
  • Bortezomib induction
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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