Induction and reversal of the magnesium deficiency syndrome in inbred mice

John Belknap, J. H. Berg, R. Cocke, A. N. Clancy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mice of the DBA 2J and C57BL 6J strains were exposed to a low-magnesium diet and the behavioral manifestations of Mg deficiency were monitored. The DBA mice were markedly more sensitive in terms of symptomatology to magnesium losses than were the C57 mice. Intracranial (0.08 meq/kg) and intraperitoneal (3.0 meq/kg) MgSO4 injections were equally fast (within 2 to 4 h) and effective in eliminating gross tremors and seizures in Mg-deficient mice. However, the total elimination of all symptoms required at least 24 h after very large (4.5 meq/kg × 2) intraperitoneal doses of MgSO4, indicating that more slowly reversing metabolic derangements secondary to Mg deficiency are responsible for the lengthy therapeutic "lag period".

Original languageEnglish (US)
Pages (from-to)506-515
Number of pages10
JournalExperimental Neurology
Volume57
Issue number2
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Magnesium Deficiency
Inbred DBA Mouse
Magnesium
Tremor
Inbred C57BL Mouse
Seizures
Diet
Injections
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Induction and reversal of the magnesium deficiency syndrome in inbred mice. / Belknap, John; Berg, J. H.; Cocke, R.; Clancy, A. N.

In: Experimental Neurology, Vol. 57, No. 2, 1977, p. 506-515.

Research output: Contribution to journalArticle

Belknap, John ; Berg, J. H. ; Cocke, R. ; Clancy, A. N. / Induction and reversal of the magnesium deficiency syndrome in inbred mice. In: Experimental Neurology. 1977 ; Vol. 57, No. 2. pp. 506-515.
@article{9c596382700443b8a4b6cb68d696f119,
title = "Induction and reversal of the magnesium deficiency syndrome in inbred mice",
abstract = "Mice of the DBA 2J and C57BL 6J strains were exposed to a low-magnesium diet and the behavioral manifestations of Mg deficiency were monitored. The DBA mice were markedly more sensitive in terms of symptomatology to magnesium losses than were the C57 mice. Intracranial (0.08 meq/kg) and intraperitoneal (3.0 meq/kg) MgSO4 injections were equally fast (within 2 to 4 h) and effective in eliminating gross tremors and seizures in Mg-deficient mice. However, the total elimination of all symptoms required at least 24 h after very large (4.5 meq/kg × 2) intraperitoneal doses of MgSO4, indicating that more slowly reversing metabolic derangements secondary to Mg deficiency are responsible for the lengthy therapeutic {"}lag period{"}.",
author = "John Belknap and Berg, {J. H.} and R. Cocke and Clancy, {A. N.}",
year = "1977",
doi = "10.1016/0014-4886(77)90085-1",
language = "English (US)",
volume = "57",
pages = "506--515",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Induction and reversal of the magnesium deficiency syndrome in inbred mice

AU - Belknap, John

AU - Berg, J. H.

AU - Cocke, R.

AU - Clancy, A. N.

PY - 1977

Y1 - 1977

N2 - Mice of the DBA 2J and C57BL 6J strains were exposed to a low-magnesium diet and the behavioral manifestations of Mg deficiency were monitored. The DBA mice were markedly more sensitive in terms of symptomatology to magnesium losses than were the C57 mice. Intracranial (0.08 meq/kg) and intraperitoneal (3.0 meq/kg) MgSO4 injections were equally fast (within 2 to 4 h) and effective in eliminating gross tremors and seizures in Mg-deficient mice. However, the total elimination of all symptoms required at least 24 h after very large (4.5 meq/kg × 2) intraperitoneal doses of MgSO4, indicating that more slowly reversing metabolic derangements secondary to Mg deficiency are responsible for the lengthy therapeutic "lag period".

AB - Mice of the DBA 2J and C57BL 6J strains were exposed to a low-magnesium diet and the behavioral manifestations of Mg deficiency were monitored. The DBA mice were markedly more sensitive in terms of symptomatology to magnesium losses than were the C57 mice. Intracranial (0.08 meq/kg) and intraperitoneal (3.0 meq/kg) MgSO4 injections were equally fast (within 2 to 4 h) and effective in eliminating gross tremors and seizures in Mg-deficient mice. However, the total elimination of all symptoms required at least 24 h after very large (4.5 meq/kg × 2) intraperitoneal doses of MgSO4, indicating that more slowly reversing metabolic derangements secondary to Mg deficiency are responsible for the lengthy therapeutic "lag period".

UR - http://www.scopus.com/inward/record.url?scp=0017763690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017763690&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(77)90085-1

DO - 10.1016/0014-4886(77)90085-1

M3 - Article

C2 - 908386

AN - SCOPUS:0017763690

VL - 57

SP - 506

EP - 515

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 2

ER -