Abstract
This chapter aims to introduce current and future uses of human embryonic stem cells (hESC) derived from in vitro fertilized embryos. These and stem cells derived from parthenogenetic and nuclear transfer embryos could be used for cell therapy, as in vitro cell models for drug discovery/screening and for studying early human development and pathogenesis of human diseases. However, development of therapeutic and screening applications and products from hESC is hampered by several barriers. Therefore, gaps in our current understanding of stem cell basic science need to be filled before either application can move forward with confidence for biopharmaceutical development.
Original language | English (US) |
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Title of host publication | Modern Biopharmaceuticals |
Subtitle of host publication | Recent Success Stories |
Publisher | Wiley-VCH |
Pages | 39-55 |
Number of pages | 17 |
ISBN (Print) | 9783527322831 |
DOIs | |
State | Published - Apr 23 2013 |
Externally published | Yes |
Keywords
- Differentiation
- Human embryonic stem cells
- Induced pluripotency
- Nuclear transfer
- Signaling pathway
- Somatic cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)