Indomethacin-sensitive monocyte killing defect in a child with disseminated atypical mycobacterial disease

Derry Ridgway; Lawrence J. Wolff; Michael Wall; Michael S. Borzy; Charles H. Kirkpatrick

doi:10.1007/BF00918801

Indomethacin-sensitive monocyte killing defect in a child with disseminated atypical mycobacterial disease

Derry Ridgway, Lawrence J. Wolff, Michael Wall, Michael S. Borzy, Charles H. Kirkpatrick

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A child with disseminated disease due to Mycobacterium avium had progressive disease in spite of 4.5 years of therapy with multiple antimicrobial agents selected on the basis of in vitro sensitivity testing of her organism. A defect in monocyte bactericidal activity was detected which was corrected in vitro by exposure of the patient's monocytes to indomethacin and normal serum. Indomethacin therapy resulted in normalization of monocyte bactericidal activity and striking, albeit temporary, clinical improvement.

Original language	English (US)
Pages (from-to)	357-362
Number of pages	6
Journal	Journal of Clinical Immunology
Volume	11
Issue number	6
DOIs	https://doi.org/10.1007/BF00918801
State	Published - Nov 1991
Externally published	Yes

Keywords

Monocyte
Mycobacterium avium complex (MAC)
bactericidal
indomethacin
mycobacterium

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/BF00918801

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title = "Indomethacin-sensitive monocyte killing defect in a child with disseminated atypical mycobacterial disease",

abstract = "A child with disseminated disease due to Mycobacterium avium had progressive disease in spite of 4.5 years of therapy with multiple antimicrobial agents selected on the basis of in vitro sensitivity testing of her organism. A defect in monocyte bactericidal activity was detected which was corrected in vitro by exposure of the patient's monocytes to indomethacin and normal serum. Indomethacin therapy resulted in normalization of monocyte bactericidal activity and striking, albeit temporary, clinical improvement.",

keywords = "Monocyte, Mycobacterium avium complex (MAC), bactericidal, indomethacin, mycobacterium",

author = "Derry Ridgway and Wolff, {Lawrence J.} and Michael Wall and Borzy, {Michael S.} and Kirkpatrick, {Charles H.}",

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AU - Ridgway, Derry

AU - Wolff, Lawrence J.

AU - Wall, Michael

AU - Borzy, Michael S.

AU - Kirkpatrick, Charles H.

PY - 1991/11

Y1 - 1991/11

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AB - A child with disseminated disease due to Mycobacterium avium had progressive disease in spite of 4.5 years of therapy with multiple antimicrobial agents selected on the basis of in vitro sensitivity testing of her organism. A defect in monocyte bactericidal activity was detected which was corrected in vitro by exposure of the patient's monocytes to indomethacin and normal serum. Indomethacin therapy resulted in normalization of monocyte bactericidal activity and striking, albeit temporary, clinical improvement.

KW - Monocyte

KW - Mycobacterium avium complex (MAC)

KW - bactericidal

KW - indomethacin

KW - mycobacterium

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Indomethacin-sensitive monocyte killing defect in a child with disseminated atypical mycobacterial disease

Abstract

Keywords

ASJC Scopus subject areas

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