Individualizing the risk/benefit ratio of NSAIDs in older patients

D. S. Sager, R. M. Bennett

    Research output: Contribution to journalReview articlepeer-review

    20 Scopus citations


    Nonsteroidal anti-inflammatory drugs (NSAIDs) have provided safe, effective relief of pain and inflammation in millions of elderly patients. Their role in the therapy of rheumatic disease, particularly in helping patients to maintain an independent lifestyle, is indisputable. Despite this success, recent epidemiologic studies have confirmed an increased relative risk for a wide variety of significant toxicities. Advanced age has emerged as one of the most striking risk factors for all of the commonly associated side effects. However, considering the large proportion of the population using these drugs, the absolute risk is remarkably low. Recognizing those elderly individuals most likely to benefit and least likely to suffer from NSAID use is the key to their appropriate use.

    Original languageEnglish (US)
    Pages (from-to)24-31
    Number of pages8
    Issue number8
    StatePublished - Jan 1 1992

    ASJC Scopus subject areas

    • Geriatrics and Gerontology


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