TY - JOUR
T1 - Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism
T2 - The GOCADAN study
AU - Ebbesson, Sven O.E.
AU - Tejero, M. Elizabeth
AU - López-Alvarenga, Juan Carlos
AU - Harris, William S.
AU - Ebbesson, Lars O.E.
AU - Devereux, Richard B.
AU - MacCluer, Jean W.
AU - Wenger, Charlotte
AU - Laston, Sandra
AU - Fabsitz, Richard R.
AU - Howard, Barbara V.
AU - Comuzzie, Anthony G.
PY - 2010
Y1 - 2010
N2 - Objectives. Type 2 diabetes and the consumption of saturated fatty acids (FAs) are on the rise among Alaska Inuits. This analysis, based on a cross-sectional study, explores the possible associations of saturated FA content in red blood cells (RBCs) and parameters of glucose metabolism in a sample of Alaska Natives. Study design and methods. The sample included 343 women and 282 men aged 35-74. Statistical analyses explored the associations of selected RBC (myristic, palmitic and stearic acids) FAs with fasting glucose (plasma), fasting insulin (plasma), 2h glucose (2-hour glucose tolerance test), 2h insulin and homeostasis model assessment (HOMA) index. The models included sex and glucose metabolism status as fixed factors and age, body mass index (BMI), waist circumference, physical activity (METS) and FA content in RBCs as covariates. Measures of insulin, glucose and HOMA index were used as dependent variables. Results. Myristic acid was positively associated with fasting insulin (β=0.47, p<0.001), 2h insulin (β=0.53, p=0.02) and HOMA index (β=0.455, p<0.001). Palmitic acid was associated with 2h glucose (β=2.3×10-2, p<0.001) and 2h insulin (β=5.6×10-2, p=0.002) and stearic acid was associated with fasting glucose (β=4.8×10-3, p=0.006). Conclusions. These results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes.
AB - Objectives. Type 2 diabetes and the consumption of saturated fatty acids (FAs) are on the rise among Alaska Inuits. This analysis, based on a cross-sectional study, explores the possible associations of saturated FA content in red blood cells (RBCs) and parameters of glucose metabolism in a sample of Alaska Natives. Study design and methods. The sample included 343 women and 282 men aged 35-74. Statistical analyses explored the associations of selected RBC (myristic, palmitic and stearic acids) FAs with fasting glucose (plasma), fasting insulin (plasma), 2h glucose (2-hour glucose tolerance test), 2h insulin and homeostasis model assessment (HOMA) index. The models included sex and glucose metabolism status as fixed factors and age, body mass index (BMI), waist circumference, physical activity (METS) and FA content in RBCs as covariates. Measures of insulin, glucose and HOMA index were used as dependent variables. Results. Myristic acid was positively associated with fasting insulin (β=0.47, p<0.001), 2h insulin (β=0.53, p=0.02) and HOMA index (β=0.455, p<0.001). Palmitic acid was associated with 2h glucose (β=2.3×10-2, p<0.001) and 2h insulin (β=5.6×10-2, p=0.002) and stearic acid was associated with fasting glucose (β=4.8×10-3, p=0.006). Conclusions. These results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes.
KW - Alaska Natives
KW - Diabetes
KW - Inuit
KW - Myristic acid
KW - Palmitic acid
KW - Saturated fat
KW - Stearic acid
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U2 - 10.3402/ijch.v69i4.17669
DO - 10.3402/ijch.v69i4.17669
M3 - Article
C2 - 20719107
AN - SCOPUS:78049247143
SN - 1239-9744
VL - 69
SP - 344
EP - 351
JO - International journal of circumpolar health
JF - International journal of circumpolar health
IS - 4
ER -