Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys

Katie M. Lebold, Kathleen (Kathy) Grant, Willard M. Freeman, Kristine Wiren, Galen W. Miller, Caitlin Kiley, Scott W. Leonard, Maret G. Traber

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Chronic ethanol self-administration induces oxidative stress and exacerbates lipid peroxidation. α-Tocopherol is a potent lipid antioxidant and vitamin that is dependent upon lipoprotein transport for tissue delivery. Methods: To evaluate the extent to which vitamin E status is deranged by excessive alcohol consumption, monkeys voluntarily drinking ethanol (1.36 to 3.98g/kg/d for 19months, n=11) were compared with nondrinkers (n=5, control). Results: Three alcohol-drinking animals developed hyperlipidemia with plasma triglyceride levels (1.8±0.9mM) double those of normolipidemic (NL) drinkers (0.6±0.2) and controls (0.6±0.3, p

Original languageEnglish (US)
Pages (from-to)474-483
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume35
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Self Administration
Macaca fascicularis
Hyperlipidemias
Vitamin E
Individuality
Alcohol Drinking
Ethanol
Alcohols
Lipids
Oxidative stress
Tocopherols
Vitamins
Lipid Peroxidation
Lipoproteins
Drinking
Haplorhini
Animals
Triglycerides
Oxidative Stress
Antioxidants

Keywords

  • α-Tocopherol
  • Apolipoproteins
  • Chronic Ethanol Consumption
  • Cynomolgus Monkeys
  • Lipids
  • Liver
  • Oxidative Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys. / Lebold, Katie M.; Grant, Kathleen (Kathy); Freeman, Willard M.; Wiren, Kristine; Miller, Galen W.; Kiley, Caitlin; Leonard, Scott W.; Traber, Maret G.

In: Alcoholism: Clinical and Experimental Research, Vol. 35, No. 3, 03.2011, p. 474-483.

Research output: Contribution to journalArticle

Lebold, Katie M. ; Grant, Kathleen (Kathy) ; Freeman, Willard M. ; Wiren, Kristine ; Miller, Galen W. ; Kiley, Caitlin ; Leonard, Scott W. ; Traber, Maret G. / Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys. In: Alcoholism: Clinical and Experimental Research. 2011 ; Vol. 35, No. 3. pp. 474-483.
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