Indications and outcomes of extracorporeal life support in trauma patients

Justyna Swol, Daniel Brodie, Lena Napolitano, Pauline K. Park, Ravi Thiagarajan, Ryan P. Barbaro, Roberto Lorusso, David McMullan, Nicholas Cavarocchi, Ali Ait Hssain, Peter Rycus, David Zonies

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

BACKGROUND The use of extracorporeal life support (ECLS) in the trauma population remains controversial and has been reported only in small cohort studies. Recent ECLS technical advances have increased its use as an advanced critical care option in trauma. Given the degree of resource utilization, costs, and expertise required to provide ECLS support in trauma patients, we sought to perform a multi-institutional study to assess the indications and outcomes of ECLS in trauma. METHODS A retrospective review of adult (≥16 years) trauma patients receiving ECLS support in the Extracorporeal Life Support Organization (ELSO) registry (1989-2016) was performed. Standardized data from the contributing ELSO centers includes patient demographics, diagnoses, and ECLS technique and procedures. Additionally, baseline characteristics, precannulation and postcannulation physiologic data, complications, and outcomes were recorded. Survival was categorized both by transition off ECLS support and survival to hospital discharge. RESULTS Two hundred seventy-nine trauma patients were identified (0.92% of 30,273 adult ECLS patients). Extracorporeal life support increased significantly in the last 5 years (173 in 2011-2016, 62%) compared with 106 in the prior 18 years. Trauma patients were predominantly male (78%), with a mean age of 34.8 ± 15.4 years (range, 16-88 years). Thoracic injury was the most common diagnosis; acute respiratory distress syndrome was the most common indication. Extracorporeal life support was venovenous for respiratory failure (89%), VA for cardiac failure (7%), and VA for ECLS-Assisted cardiopulmonary resuscitation (CPR) (E-CPR) (4%). Extracorporeal life support duration was 8.8 ± 9.5 days (longest 83 days), and was longer for respiratory support (9.3 ± 9.3 days) vs. cardiac support (4.1 ± 4.5 days) and E-CPR (6.5 ± 16.8 days). Overall survival from ECLS was 70% and survival to hospital discharge was 61% in the total cohort (63% respiratory, 50% cardiac, 25% E-CPR), similar to survival rates in other ELSO registry cohorts. More than 80% of patients had a reported complication during ECLS support. The most common complication was cardiovascular (51%) followed by a bleeding complication (29%). Multiple organ failure was the most common cause of death (15.4%). CONCLUSION Data from the largest registry of critically ill trauma patients receiving ECLS support demonstrates reasonable survival. With growing experience and improved safety profile, trauma should not be considered a contraindication for ECLS. Further analysis of the ELSO registry regarding trauma-specific risk factors and ECLS-specific practices may identify best candidates and improve trauma ECLS outcomes. LEVEL OF EVIDENCE Therapeutic study, level III.

Original languageEnglish (US)
Pages (from-to)831-837
Number of pages7
JournalJournal of Trauma and Acute Care Surgery
Volume84
Issue number6
DOIs
StatePublished - Jun 1 2018

Keywords

  • ARDS
  • Trauma
  • cardiac failure
  • extracorporeal life support
  • extracorporeal membrane oxygenation
  • respiratory failure

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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    Swol, J., Brodie, D., Napolitano, L., Park, P. K., Thiagarajan, R., Barbaro, R. P., Lorusso, R., McMullan, D., Cavarocchi, N., Hssain, A. A., Rycus, P., & Zonies, D. (2018). Indications and outcomes of extracorporeal life support in trauma patients. Journal of Trauma and Acute Care Surgery, 84(6), 831-837. https://doi.org/10.1097/TA.0000000000001895