Increases of glial fibrillary acidic protein in the aging female mouse brain

Steven G. Kohama; James R. Goss; Caleb E. Finch; Thomas H. McNeill

doi:10.1016/0197-4580(95)80008-F

Increases of glial fibrillary acidic protein in the aging female mouse brain

Steven G. Kohama, James R. Goss, Caleb E. Finch, Thomas H. McNeill

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry in female C57BL/6J mice. The age groups represented the major stages of reproductive aging: young (5 months), middle-age (18 months), and old (23 and 26 months). GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA. Gray matter showed robust ≥ twofold increases in GFAP mRNA with age, especially in the thalamus and hypothalamus, areas that expressed little GFAP in the young. These generalized age-related increases of GFAP in many brain regions imply the existence of a widespread stimulus for increased activity of astrocytes during aging.

Original language	English (US)
Pages (from-to)	59-67
Number of pages	9
Journal	Neurobiology of Aging
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0197-4580(95)80008-F
State	Published - 1995
Externally published	Yes

Keywords

GFAP Brain In situ hybridization Immunocytochemistry Aging Mouse White matter Gray matter

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(95)80008-F

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title = "Increases of glial fibrillary acidic protein in the aging female mouse brain",

abstract = "Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry in female C57BL/6J mice. The age groups represented the major stages of reproductive aging: young (5 months), middle-age (18 months), and old (23 and 26 months). GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA. Gray matter showed robust ≥ twofold increases in GFAP mRNA with age, especially in the thalamus and hypothalamus, areas that expressed little GFAP in the young. These generalized age-related increases of GFAP in many brain regions imply the existence of a widespread stimulus for increased activity of astrocytes during aging.",

keywords = "GFAP Brain In situ hybridization Immunocytochemistry Aging Mouse White matter Gray matter",

author = "Kohama, {Steven G.} and Goss, {James R.} and Finch, {Caleb E.} and McNeill, {Thomas H.}",

note = "Funding Information: This work was supported by AG 00037 (S.G.K.), AG 09793, NS 30426 (T.H.M. and S.G.K.), and AG 7909 (C.E.F.).",

year = "1995",

doi = "10.1016/0197-4580(95)80008-F",

language = "English (US)",

volume = "16",

pages = "59--67",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "1",

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T1 - Increases of glial fibrillary acidic protein in the aging female mouse brain

AU - Kohama, Steven G.

AU - Goss, James R.

AU - Finch, Caleb E.

AU - McNeill, Thomas H.

N1 - Funding Information: This work was supported by AG 00037 (S.G.K.), AG 09793, NS 30426 (T.H.M. and S.G.K.), and AG 7909 (C.E.F.).

PY - 1995

Y1 - 1995

N2 - Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry in female C57BL/6J mice. The age groups represented the major stages of reproductive aging: young (5 months), middle-age (18 months), and old (23 and 26 months). GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA. Gray matter showed robust ≥ twofold increases in GFAP mRNA with age, especially in the thalamus and hypothalamus, areas that expressed little GFAP in the young. These generalized age-related increases of GFAP in many brain regions imply the existence of a widespread stimulus for increased activity of astrocytes during aging.

AB - Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry in female C57BL/6J mice. The age groups represented the major stages of reproductive aging: young (5 months), middle-age (18 months), and old (23 and 26 months). GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA. Gray matter showed robust ≥ twofold increases in GFAP mRNA with age, especially in the thalamus and hypothalamus, areas that expressed little GFAP in the young. These generalized age-related increases of GFAP in many brain regions imply the existence of a widespread stimulus for increased activity of astrocytes during aging.

KW - GFAP Brain In situ hybridization Immunocytochemistry Aging Mouse White matter Gray matter

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JO - Neurobiology of Aging

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IS - 1

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Increases of glial fibrillary acidic protein in the aging female mouse brain

Abstract

Keywords

ASJC Scopus subject areas

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