Increases of glial fibrillary acidic protein in the aging female mouse brain

Steven Kohama, James R. Goss, Caleb E. Finch, Thomas H. McNeill

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry in female C57BL/6J mice. The age groups represented the major stages of reproductive aging: young (5 months), middle-age (18 months), and old (23 and 26 months). GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA. Gray matter showed robust ≥ twofold increases in GFAP mRNA with age, especially in the thalamus and hypothalamus, areas that expressed little GFAP in the young. These generalized age-related increases of GFAP in many brain regions imply the existence of a widespread stimulus for increased activity of astrocytes during aging.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalNeurobiology of Aging
Volume16
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Glial Fibrillary Acidic Protein
Brain
Astrocytes
Messenger RNA
Corpus Callosum
Thalamus
Inbred C57BL Mouse
Hypothalamus
In Situ Hybridization
Age Groups
Immunohistochemistry
Proteins

Keywords

  • GFAP Brain In situ hybridization Immunocytochemistry Aging Mouse White matter Gray matter

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Increases of glial fibrillary acidic protein in the aging female mouse brain. / Kohama, Steven; Goss, James R.; Finch, Caleb E.; McNeill, Thomas H.

In: Neurobiology of Aging, Vol. 16, No. 1, 1995, p. 59-67.

Research output: Contribution to journalArticle

Kohama, Steven ; Goss, James R. ; Finch, Caleb E. ; McNeill, Thomas H. / Increases of glial fibrillary acidic protein in the aging female mouse brain. In: Neurobiology of Aging. 1995 ; Vol. 16, No. 1. pp. 59-67.
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