Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation

Frederick (Fred) Tibayan, Filiberto Rodriguez, Frank Langer, Mary K. Zasio, Lynn Bailey David Liang, George T. Daughters, Matts Karlsson, Neil B. Ingels, D. Craig Miller

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background and aim of the study: Leaflet curvature is a primary determinant of leaflet stress, but no quantitative in-vivo leaflet curvature data exist. Chronic ischemic mitral regurgitation (CIMR) is associated with remodeling of the valvular-ventricular complex. It was hypothesized that leaflet radii of curvature (ROC) would change with such remodeling. Methods: Twelve sheep had placement of radiopaque markers on the anterior (APM) and posterior (PPM) papillary muscles, mitral annulus, and anterior (AL) and posterior leaflet (PL) midlines. After 8 ± 2 days, videofluoroscopy provided baseline 3-D marker data prior to creating inferior myocardial infarction (MI) by snare occlusion of the obtuse marginal coronary arteries. After 7 ± 1 weeks, the animals were re-studied; 3-D marker coordinates were used to determine end-systolic leaflet ROC, leaflet length, annular septal-lateral diameter, and the distance of each papillary muscle to the mid-septal annulus and each commissure. Results: Before and after CIMR, the AL had compound curvature, and CIMR increased ROC of both curves (proximal ROC 1.27 ± 0.59 to 1.38 ± 0.60 cm (p

Original languageEnglish (US)
Pages (from-to)772-778
Number of pages7
JournalJournal of Heart Valve Disease
Volume13
Issue number5
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

Mitral Valve Insufficiency
Papillary Muscles
Inferior Wall Myocardial Infarction
Ventricular Remodeling
Sheep
Coronary Vessels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tibayan, F. F., Rodriguez, F., Langer, F., Zasio, M. K., Liang, L. B. D., Daughters, G. T., ... Craig Miller, D. (2004). Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation. Journal of Heart Valve Disease, 13(5), 772-778.

Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation. / Tibayan, Frederick (Fred); Rodriguez, Filiberto; Langer, Frank; Zasio, Mary K.; Liang, Lynn Bailey David; Daughters, George T.; Karlsson, Matts; Ingels, Neil B.; Craig Miller, D.

In: Journal of Heart Valve Disease, Vol. 13, No. 5, 09.2004, p. 772-778.

Research output: Contribution to journalArticle

Tibayan, FF, Rodriguez, F, Langer, F, Zasio, MK, Liang, LBD, Daughters, GT, Karlsson, M, Ingels, NB & Craig Miller, D 2004, 'Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation', Journal of Heart Valve Disease, vol. 13, no. 5, pp. 772-778.
Tibayan FF, Rodriguez F, Langer F, Zasio MK, Liang LBD, Daughters GT et al. Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation. Journal of Heart Valve Disease. 2004 Sep;13(5):772-778.
Tibayan, Frederick (Fred) ; Rodriguez, Filiberto ; Langer, Frank ; Zasio, Mary K. ; Liang, Lynn Bailey David ; Daughters, George T. ; Karlsson, Matts ; Ingels, Neil B. ; Craig Miller, D. / Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation. In: Journal of Heart Valve Disease. 2004 ; Vol. 13, No. 5. pp. 772-778.
@article{a12cd0e02bac480ab29661632e0c6859,
title = "Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation",
abstract = "Background and aim of the study: Leaflet curvature is a primary determinant of leaflet stress, but no quantitative in-vivo leaflet curvature data exist. Chronic ischemic mitral regurgitation (CIMR) is associated with remodeling of the valvular-ventricular complex. It was hypothesized that leaflet radii of curvature (ROC) would change with such remodeling. Methods: Twelve sheep had placement of radiopaque markers on the anterior (APM) and posterior (PPM) papillary muscles, mitral annulus, and anterior (AL) and posterior leaflet (PL) midlines. After 8 ± 2 days, videofluoroscopy provided baseline 3-D marker data prior to creating inferior myocardial infarction (MI) by snare occlusion of the obtuse marginal coronary arteries. After 7 ± 1 weeks, the animals were re-studied; 3-D marker coordinates were used to determine end-systolic leaflet ROC, leaflet length, annular septal-lateral diameter, and the distance of each papillary muscle to the mid-septal annulus and each commissure. Results: Before and after CIMR, the AL had compound curvature, and CIMR increased ROC of both curves (proximal ROC 1.27 ± 0.59 to 1.38 ± 0.60 cm (p",
author = "Tibayan, {Frederick (Fred)} and Filiberto Rodriguez and Frank Langer and Zasio, {Mary K.} and Liang, {Lynn Bailey David} and Daughters, {George T.} and Matts Karlsson and Ingels, {Neil B.} and {Craig Miller}, D.",
year = "2004",
month = "9",
language = "English (US)",
volume = "13",
pages = "772--778",
journal = "The Journal of heart valve disease",
issn = "0966-8519",
publisher = "ICR Publishers Ltd",
number = "5",

}

TY - JOUR

T1 - Increases in mitral leaflet radii of curvature with chronic ischemic mitral regurgitation

AU - Tibayan, Frederick (Fred)

AU - Rodriguez, Filiberto

AU - Langer, Frank

AU - Zasio, Mary K.

AU - Liang, Lynn Bailey David

AU - Daughters, George T.

AU - Karlsson, Matts

AU - Ingels, Neil B.

AU - Craig Miller, D.

PY - 2004/9

Y1 - 2004/9

N2 - Background and aim of the study: Leaflet curvature is a primary determinant of leaflet stress, but no quantitative in-vivo leaflet curvature data exist. Chronic ischemic mitral regurgitation (CIMR) is associated with remodeling of the valvular-ventricular complex. It was hypothesized that leaflet radii of curvature (ROC) would change with such remodeling. Methods: Twelve sheep had placement of radiopaque markers on the anterior (APM) and posterior (PPM) papillary muscles, mitral annulus, and anterior (AL) and posterior leaflet (PL) midlines. After 8 ± 2 days, videofluoroscopy provided baseline 3-D marker data prior to creating inferior myocardial infarction (MI) by snare occlusion of the obtuse marginal coronary arteries. After 7 ± 1 weeks, the animals were re-studied; 3-D marker coordinates were used to determine end-systolic leaflet ROC, leaflet length, annular septal-lateral diameter, and the distance of each papillary muscle to the mid-septal annulus and each commissure. Results: Before and after CIMR, the AL had compound curvature, and CIMR increased ROC of both curves (proximal ROC 1.27 ± 0.59 to 1.38 ± 0.60 cm (p

AB - Background and aim of the study: Leaflet curvature is a primary determinant of leaflet stress, but no quantitative in-vivo leaflet curvature data exist. Chronic ischemic mitral regurgitation (CIMR) is associated with remodeling of the valvular-ventricular complex. It was hypothesized that leaflet radii of curvature (ROC) would change with such remodeling. Methods: Twelve sheep had placement of radiopaque markers on the anterior (APM) and posterior (PPM) papillary muscles, mitral annulus, and anterior (AL) and posterior leaflet (PL) midlines. After 8 ± 2 days, videofluoroscopy provided baseline 3-D marker data prior to creating inferior myocardial infarction (MI) by snare occlusion of the obtuse marginal coronary arteries. After 7 ± 1 weeks, the animals were re-studied; 3-D marker coordinates were used to determine end-systolic leaflet ROC, leaflet length, annular septal-lateral diameter, and the distance of each papillary muscle to the mid-septal annulus and each commissure. Results: Before and after CIMR, the AL had compound curvature, and CIMR increased ROC of both curves (proximal ROC 1.27 ± 0.59 to 1.38 ± 0.60 cm (p

UR - http://www.scopus.com/inward/record.url?scp=7444265935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7444265935&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 772

EP - 778

JO - The Journal of heart valve disease

JF - The Journal of heart valve disease

SN - 0966-8519

IS - 5

ER -