Increased vitamin E intake is associated with higher α-tocopherol concentration in the maternal circulation but higher α-carboxyethyl hydroxychroman concentration in the fetal circulation

Svetlana Didenco, Melanie Gillingham, Mitzi D. Go, Scott W. Leonard, Maret G. Traber, Cynthia (Cindy) McEvoy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The transfer of vitamin E across the placenta is limited, but no data exist on the concentrations of vitamin E metabolites carboxyethyl hydroxychromans (α- and γ-CEHCs) in the fetal circulation. Objective: We measured α- and γ-CEHC concentrations in maternal and umbilical cord blood pairs and examined their relations to circulating vitamin E (α- and γ-tocopherol) and maternal dietary vitamin E intake. Design: Healthy, pregnant women were enrolled from Oregon Health and Science University's obstetric clinic (

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume93
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Tocopherols
Vitamin E
Mothers
Fetal Blood
Placenta
Obstetrics
Pregnant Women
carboxyethyl-hydroxychroman
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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T1 - Increased vitamin E intake is associated with higher α-tocopherol concentration in the maternal circulation but higher α-carboxyethyl hydroxychroman concentration in the fetal circulation

AU - Didenco, Svetlana

AU - Gillingham, Melanie

AU - Go, Mitzi D.

AU - Leonard, Scott W.

AU - Traber, Maret G.

AU - McEvoy, Cynthia (Cindy)

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AB - Background: The transfer of vitamin E across the placenta is limited, but no data exist on the concentrations of vitamin E metabolites carboxyethyl hydroxychromans (α- and γ-CEHCs) in the fetal circulation. Objective: We measured α- and γ-CEHC concentrations in maternal and umbilical cord blood pairs and examined their relations to circulating vitamin E (α- and γ-tocopherol) and maternal dietary vitamin E intake. Design: Healthy, pregnant women were enrolled from Oregon Health and Science University's obstetric clinic (

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