Increased vascular resistance during complement-activated plasma infusion in swine

L. J. Swenson, George Pantely, C. G. Anselone, J. D. Bristow

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To investigate the acute effects of complement activation on blood flow, we infused complement-activated plasma into the femoral artery of the isolated hindlimb of 19 anesthetized swine. Femoral artery blood flow decreased abruptly, was lowest at 1 min of the infusion, and thereafter slowly increased despite continued infusion. There was no significant change in femoral artery pressure or femoral vein pressure, confirming an acute increase in vascular resistance. Control infusion of heat-decomplemented-activated plasma caused no change in pressure or flow. Slope of the femoral artery pressure-flow relationship during maximal vasodilation with adenosine was significantly lower after infusion of complement-activated plasma, confirming a persistent increase in vascular resistance. Neither the acute nor the persistent increase in vascular resistance was prevented by α-adrenergic blockade with phentolamine or granulocytopenia produced by cyclophosphamide. We conclude that complement-activated plasma infusion in the femoral circulation causes an abrupt increase in vascular resistance that persists during pharmacologically maximal vasodilation, is not due to α-mediated vasoconstriction, and is not altered by severe granulocytopenia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume253
Issue number1
StatePublished - 1987
Externally publishedYes

Fingerprint

Femoral Artery
Vascular Resistance
Swine
Pressure
Agranulocytosis
Vasodilation
Femoral Vein
Phentolamine
Complement Activation
Hindlimb
Thigh
Vasoconstriction
Adrenergic Agents
Adenosine
Cyclophosphamide
Hot Temperature

ASJC Scopus subject areas

  • Physiology

Cite this

Increased vascular resistance during complement-activated plasma infusion in swine. / Swenson, L. J.; Pantely, George; Anselone, C. G.; Bristow, J. D.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 253, No. 1, 1987.

Research output: Contribution to journalArticle

Swenson, L. J. ; Pantely, George ; Anselone, C. G. ; Bristow, J. D. / Increased vascular resistance during complement-activated plasma infusion in swine. In: American Journal of Physiology - Heart and Circulatory Physiology. 1987 ; Vol. 253, No. 1.
@article{da43f02b968e4cacb43239cd089805c6,
title = "Increased vascular resistance during complement-activated plasma infusion in swine",
abstract = "To investigate the acute effects of complement activation on blood flow, we infused complement-activated plasma into the femoral artery of the isolated hindlimb of 19 anesthetized swine. Femoral artery blood flow decreased abruptly, was lowest at 1 min of the infusion, and thereafter slowly increased despite continued infusion. There was no significant change in femoral artery pressure or femoral vein pressure, confirming an acute increase in vascular resistance. Control infusion of heat-decomplemented-activated plasma caused no change in pressure or flow. Slope of the femoral artery pressure-flow relationship during maximal vasodilation with adenosine was significantly lower after infusion of complement-activated plasma, confirming a persistent increase in vascular resistance. Neither the acute nor the persistent increase in vascular resistance was prevented by α-adrenergic blockade with phentolamine or granulocytopenia produced by cyclophosphamide. We conclude that complement-activated plasma infusion in the femoral circulation causes an abrupt increase in vascular resistance that persists during pharmacologically maximal vasodilation, is not due to α-mediated vasoconstriction, and is not altered by severe granulocytopenia.",
author = "Swenson, {L. J.} and George Pantely and Anselone, {C. G.} and Bristow, {J. D.}",
year = "1987",
language = "English (US)",
volume = "253",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Increased vascular resistance during complement-activated plasma infusion in swine

AU - Swenson, L. J.

AU - Pantely, George

AU - Anselone, C. G.

AU - Bristow, J. D.

PY - 1987

Y1 - 1987

N2 - To investigate the acute effects of complement activation on blood flow, we infused complement-activated plasma into the femoral artery of the isolated hindlimb of 19 anesthetized swine. Femoral artery blood flow decreased abruptly, was lowest at 1 min of the infusion, and thereafter slowly increased despite continued infusion. There was no significant change in femoral artery pressure or femoral vein pressure, confirming an acute increase in vascular resistance. Control infusion of heat-decomplemented-activated plasma caused no change in pressure or flow. Slope of the femoral artery pressure-flow relationship during maximal vasodilation with adenosine was significantly lower after infusion of complement-activated plasma, confirming a persistent increase in vascular resistance. Neither the acute nor the persistent increase in vascular resistance was prevented by α-adrenergic blockade with phentolamine or granulocytopenia produced by cyclophosphamide. We conclude that complement-activated plasma infusion in the femoral circulation causes an abrupt increase in vascular resistance that persists during pharmacologically maximal vasodilation, is not due to α-mediated vasoconstriction, and is not altered by severe granulocytopenia.

AB - To investigate the acute effects of complement activation on blood flow, we infused complement-activated plasma into the femoral artery of the isolated hindlimb of 19 anesthetized swine. Femoral artery blood flow decreased abruptly, was lowest at 1 min of the infusion, and thereafter slowly increased despite continued infusion. There was no significant change in femoral artery pressure or femoral vein pressure, confirming an acute increase in vascular resistance. Control infusion of heat-decomplemented-activated plasma caused no change in pressure or flow. Slope of the femoral artery pressure-flow relationship during maximal vasodilation with adenosine was significantly lower after infusion of complement-activated plasma, confirming a persistent increase in vascular resistance. Neither the acute nor the persistent increase in vascular resistance was prevented by α-adrenergic blockade with phentolamine or granulocytopenia produced by cyclophosphamide. We conclude that complement-activated plasma infusion in the femoral circulation causes an abrupt increase in vascular resistance that persists during pharmacologically maximal vasodilation, is not due to α-mediated vasoconstriction, and is not altered by severe granulocytopenia.

UR - http://www.scopus.com/inward/record.url?scp=0023225889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023225889&partnerID=8YFLogxK

M3 - Article

VL - 253

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 1

ER -