Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patients

Zheng Li, Dan H. Moore, Zhen Hang Meng, Britt Marie Ljung, Joe W. Gray, Joe Gray

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Allelic losses characteristic of tumor cells, when displayed by morphologically normal terminal ductal lobular units (TDLUs) adjacent to carcinoma [G. Deng et al., Science (Wash. DC), 274: 2057-2059, 1996], may indicate an extended field of increased cancer susceptibility within the affected breast tissue. We investigated this possibility by asking whether the presence of loss of heterozygosity (LOH) at chromosome 3p11-26 in histologically normal TDLUs (3pLOHn) could lead to an increased risk of local tumor recurrence. We assessed LOHs in normal TDLUs adjacent to 48 informative cases of early-stage invasive breast cancer samples and found 3pLOHn in ∼25% (13 of 48) of patients whose tumors had 3pLOH in this region. Our analyses suggest that the most frequent region of LOH is localized at 3p24.3. We also demonstrate, using a Cox proportional hazards regression model, that the presence of 3pLOHn was the only variable significantly related to local tumor recurrence, leading to a 3.9-5.2-fold increase in the hazard ratio (P <0.05). The time to recurrence was longer in such cases than in those without 3pLOHn, suggesting de novo tumor development. These data provide a strong rationale to assess histologically normal breast tissue at the margins of surgically excised cancers for molecular predictors of local recurrence after breast-conserving treatment.

Original languageEnglish (US)
Pages (from-to)1000-1003
Number of pages4
JournalCancer Research
Volume62
Issue number4
StatePublished - 2002
Externally publishedYes

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Loss of Heterozygosity
Breast Neoplasms
Recurrence
Neoplasms
Breast
Proportional Hazards Models
Chromosomes
Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patients. / Li, Zheng; Moore, Dan H.; Meng, Zhen Hang; Ljung, Britt Marie; Gray, Joe W.; Gray, Joe.

In: Cancer Research, Vol. 62, No. 4, 2002, p. 1000-1003.

Research output: Contribution to journalArticle

Li, Z, Moore, DH, Meng, ZH, Ljung, BM, Gray, JW & Gray, J 2002, 'Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patients', Cancer Research, vol. 62, no. 4, pp. 1000-1003.
Li, Zheng ; Moore, Dan H. ; Meng, Zhen Hang ; Ljung, Britt Marie ; Gray, Joe W. ; Gray, Joe. / Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patients. In: Cancer Research. 2002 ; Vol. 62, No. 4. pp. 1000-1003.
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