Increased Prevalence of Regurgitant Valvular Heart Disease in Acromegaly

Alberto M. Pereira, Sjoerd W. Van Thiel, Jonathan Lindner, Ferdinand Roelfsema, Ernst E. Van Der Wall, Hans Morreau, Jan W A Smit, Johannes A. Romijn, Jeroen J. Bax

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Cardiac involvement is common in acromegaly, but the prevalence of valvular abnormalities in patients with acromegaly has not been documented and is the topic of this study. In a prospective study design, 40 consecutive patients with acromegaly and 120 control subjects (matched for age, sex, hypertension, and left ventricular systolic function) were studied. All patients and controls were evaluated using conventional two-dimensional and Doppler echocardiography. Significant valve disease was more prevalent in acromegalics compared with controls (22% vs. 6.7%, respectively; P = 0.005). Aortic valve regurgitation (≥trace severity) was present in 30% of patients vs. 7% of controls (P <0.001), and mitral regurgitation (≥moderate severity) was absent in controis but present in 5% of acromegalics (P = 0.014 vs. controls). Binary logistic regression analysis showed a significant impact only for disease duration on valvular disease, with an odds ratio of 1.19 (95% confidence interval, 1.028-1.376; P = 0.019). Acromegaly is associated with an increased prevalence of regurgitant valvular heart disease. This is dependent on the duration of exposure to increased GH concentrations, with a 19% increase in odds per year. This increased prevalence of occult valvular disease indicates that these patients require appropriate follow-up care and monitoring, especially patients with inadequate control of GH overproduction. (J Clin Endocrinol Metab 89: 71-75, 2004).

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

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Heart Valve Diseases
Acromegaly
Aftercare
Aortic Valve Insufficiency
Doppler Echocardiography
Mitral Valve Insufficiency
Echocardiography
Patient monitoring
Physiologic Monitoring
Left Ventricular Function
Regression analysis
Logistic Models
Odds Ratio
Regression Analysis
Logistics
Prospective Studies
Confidence Intervals
Hypertension

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Pereira, A. M., Van Thiel, S. W., Lindner, J., Roelfsema, F., Van Der Wall, E. E., Morreau, H., ... Bax, J. J. (2004). Increased Prevalence of Regurgitant Valvular Heart Disease in Acromegaly. Journal of Clinical Endocrinology and Metabolism, 89(1), 71-75. https://doi.org/10.1210/jc.2003-030849

Increased Prevalence of Regurgitant Valvular Heart Disease in Acromegaly. / Pereira, Alberto M.; Van Thiel, Sjoerd W.; Lindner, Jonathan; Roelfsema, Ferdinand; Van Der Wall, Ernst E.; Morreau, Hans; Smit, Jan W A; Romijn, Johannes A.; Bax, Jeroen J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 1, 01.2004, p. 71-75.

Research output: Contribution to journalArticle

Pereira, AM, Van Thiel, SW, Lindner, J, Roelfsema, F, Van Der Wall, EE, Morreau, H, Smit, JWA, Romijn, JA & Bax, JJ 2004, 'Increased Prevalence of Regurgitant Valvular Heart Disease in Acromegaly', Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 1, pp. 71-75. https://doi.org/10.1210/jc.2003-030849
Pereira, Alberto M. ; Van Thiel, Sjoerd W. ; Lindner, Jonathan ; Roelfsema, Ferdinand ; Van Der Wall, Ernst E. ; Morreau, Hans ; Smit, Jan W A ; Romijn, Johannes A. ; Bax, Jeroen J. / Increased Prevalence of Regurgitant Valvular Heart Disease in Acromegaly. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 1. pp. 71-75.
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