Abstract
Recent clinical and laboratory observations support a potential role for the platelet FcγRIIA receptor (FcR) in collagen-mediated platelet activation associated with arterial thrombosis. Stable age- and sex-independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non-diabetes patients (P < 0.001). Aggregation studies following FcR cross-linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation (P = 0.018). Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.
Original language | English (US) |
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Pages (from-to) | 139-142 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 121 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2003 |
Externally published | Yes |
Keywords
- Blood platelets
- Cardiovascular disease
- Collagen
- Diabetes mellitus
- Fc
- Receptors
ASJC Scopus subject areas
- Hematology