Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus

David Calverley, Michele R. Hacker, Kimberly A. Loda, Elizabeth Brass, Thomas A. Buchanan, Denice D. Tsao-Wei, Susan Groshen

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Recent clinical and laboratory observations support a potential role for the platelet FcγRIIA receptor (FcR) in collagen-mediated platelet activation associated with arterial thrombosis. Stable age- and sex-independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non-diabetes patients (P <0.001). Aggregation studies following FcR cross-linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation (P = 0.018). Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalBritish Journal of Haematology
Volume121
Issue number1
DOIs
Publication statusPublished - Apr 2003
Externally publishedYes

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Keywords

  • Blood platelets
  • Cardiovascular disease
  • Collagen
  • Diabetes mellitus
  • Fc
  • Receptors

ASJC Scopus subject areas

  • Hematology

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