Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus

David C. Calverley, Michele R. Hacker, Kimberly A. Loda, Elizabeth Brass, Thomas A. Buchanan, Denice D. Tsao-Wei, Susan Groshen

    Research output: Contribution to journalArticle

    37 Scopus citations

    Abstract

    Recent clinical and laboratory observations support a potential role for the platelet FcγRIIA receptor (FcR) in collagen-mediated platelet activation associated with arterial thrombosis. Stable age- and sex-independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non-diabetes patients (P < 0.001). Aggregation studies following FcR cross-linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation (P = 0.018). Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.

    Original languageEnglish (US)
    Pages (from-to)139-142
    Number of pages4
    JournalBritish Journal of Haematology
    Volume121
    Issue number1
    DOIs
    StatePublished - Apr 1 2003

    Keywords

    • Blood platelets
    • Cardiovascular disease
    • Collagen
    • Diabetes mellitus
    • Fc
    • Receptors

    ASJC Scopus subject areas

    • Hematology

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