Increased Pelvic Vein Thrombi in Cryptogenic Stroke: Results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) Study

Steven C. Cramer, Guy Rordorf, Jeffrey H. Maki, Larry A. Kramer, James C. Grotta, W. Scott Burgin, Judith A. Hinchey, Curtis Benesch, Karen L. Furie, Helmi Lutsep, Ellen Kelly, W. T. Longstreth

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Background and Purpose-Cryptogenic stroke is associated with an increased prevalence of patent foramen ovale. The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT). Methods-At 5 sites, patients 18 to 60 years of age received an MRI venogram (MRV) of the pelvis within 72 hours of new symptom onset. Clinical data were then determined. Radiologists blinded to clinical data later read the scans. Results-The 95 patients who met entry criteria were scanned. Their mean±SD age was 46±10 years, and time from stroke onset to pelvic MRV scan was 49±16 hours. Compared with those with stroke of determined origin (n=49), patients with cryptogenic stroke (n=46) were significantly younger, had a higher prevalence of patent foramen ovale (61% versus 19%), and had less atherosclerosis risk factors. Cryptogenic patients had more MRV scans with a high probability for pelvic DVT (20%) than patients with stroke of determined origin (4%, P

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalStroke
Volume35
Issue number1
DOIs
StatePublished - Jan 2004

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Embolism
Veins
Thrombosis
Stroke
Patent Foramen Ovale
Venous Thrombosis
Magnetic Resonance Imaging
Pelvis
Atherosclerosis

Keywords

  • Deep vein thrombosis
  • Embolism, paradoxical
  • Etiology
  • Pathophysiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Cramer, S. C., Rordorf, G., Maki, J. H., Kramer, L. A., Grotta, J. C., Burgin, W. S., ... Longstreth, W. T. (2004). Increased Pelvic Vein Thrombi in Cryptogenic Stroke: Results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) Study. Stroke, 35(1), 46-50. https://doi.org/10.1161/01.STR.0000106137.42649.AB

Increased Pelvic Vein Thrombi in Cryptogenic Stroke : Results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) Study. / Cramer, Steven C.; Rordorf, Guy; Maki, Jeffrey H.; Kramer, Larry A.; Grotta, James C.; Burgin, W. Scott; Hinchey, Judith A.; Benesch, Curtis; Furie, Karen L.; Lutsep, Helmi; Kelly, Ellen; Longstreth, W. T.

In: Stroke, Vol. 35, No. 1, 01.2004, p. 46-50.

Research output: Contribution to journalArticle

Cramer, SC, Rordorf, G, Maki, JH, Kramer, LA, Grotta, JC, Burgin, WS, Hinchey, JA, Benesch, C, Furie, KL, Lutsep, H, Kelly, E & Longstreth, WT 2004, 'Increased Pelvic Vein Thrombi in Cryptogenic Stroke: Results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) Study', Stroke, vol. 35, no. 1, pp. 46-50. https://doi.org/10.1161/01.STR.0000106137.42649.AB
Cramer, Steven C. ; Rordorf, Guy ; Maki, Jeffrey H. ; Kramer, Larry A. ; Grotta, James C. ; Burgin, W. Scott ; Hinchey, Judith A. ; Benesch, Curtis ; Furie, Karen L. ; Lutsep, Helmi ; Kelly, Ellen ; Longstreth, W. T. / Increased Pelvic Vein Thrombi in Cryptogenic Stroke : Results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) Study. In: Stroke. 2004 ; Vol. 35, No. 1. pp. 46-50.
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