Increased paraoxon detection by acetylcholinesterase inactivation with ionic liquid additives

Chengdong Zhang, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

This is the first study using ionic liquids (ILs) as additive in the aqueous solvent medium for detection of paraoxon by acetylcholinesterase inhibition method. A systematic comparison of various ILs with organic solvents has been made. The aqueous buffer solution containing ionic liquid ethylpyridinium hexafluorophosphate [EtPy]+[PF6] - has been found to give the best results. The inhibition kinetic follows the first order model. Ionic liquids modified aqueous solutions show the potential to provide a promising and effective medium in detection of paraoxon with acetylcholinesterase.

Original languageEnglish (US)
Pages (from-to)560-563
Number of pages4
JournalTalanta
Volume67
Issue number3
DOIs
StatePublished - Sep 15 2005
Externally publishedYes

Keywords

  • Acetylcholinesterase
  • Imidazolium
  • Ionic liquids
  • Paraoxon
  • Pyridinium

ASJC Scopus subject areas

  • Analytical Chemistry

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