Increased nitric oxide production in patients with systemic sclerosis

Archana Sud, Madhu Khullar, Ajay Wanchu, Pradeep Bambery

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Nitric oxide (NO, nitrogen monoxide) is a messenger molecule whose synthesis can be induced by proinflammatory cytokines. Increased production of NO has been reported in various inflammatory and autoimmune diseases. We studied serum nitrite and citrulline as surrogate markers for NO production in patients with systemic sclerosis (SSc) and looked for correlation with extent of disease, disease duration, age, and systemic involvement. Thirty-four patients were studied against 20 controls. The nitrite levels were significantly higher in the disease group (1588.4 ± 998.2 nmol/ml compared to 327.8 ± 137.7 nmol/ml; P <0.001). The citrulline levels of the disease group were also significantly higher (5490.1 ± 2518.3 nmol/ml compared to 3264.5 ± 2509.7 nmol/ml in the controls; P = 0.005). There was no significant difference among limited and diffuse subgroups. There was no significant difference in patients with or without arthritis or interstitial lung disease or with other systemic involvement. On multivariate analysis there was a trend toward a rising level of nitrite with worsening lung functions (P = 0.07). Hence, there is evidence of increased NO production in patients with SSc. There is no difference between NO levels in disease subgroups or those with systemic involvement.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
JournalNitric Oxide - Biology and Chemistry
Volume4
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Systemic Scleroderma
Nitric Oxide
Nitrites
Citrulline
Interstitial Lung Diseases
Pulmonary diseases
Autoimmune Diseases
Arthritis
Multivariate Analysis
Biomarkers
Cytokines
Lung
Molecules
Serum

Keywords

  • Progressive systemic sclerosis
  • Reactive nitrogen inter-mediates
  • Scleroderma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Increased nitric oxide production in patients with systemic sclerosis. / Sud, Archana; Khullar, Madhu; Wanchu, Ajay; Bambery, Pradeep.

In: Nitric Oxide - Biology and Chemistry, Vol. 4, No. 6, 2000, p. 615-619.

Research output: Contribution to journalArticle

Sud, Archana ; Khullar, Madhu ; Wanchu, Ajay ; Bambery, Pradeep. / Increased nitric oxide production in patients with systemic sclerosis. In: Nitric Oxide - Biology and Chemistry. 2000 ; Vol. 4, No. 6. pp. 615-619.
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