TY - JOUR
T1 - Increased mast cell infiltration in varicose veins of the lower limbs
T2 - A possible role in the development of varices
AU - Yamada, T.
AU - Tomita, S.
AU - Mori, M.
AU - Sasatomi, E.
AU - Suenaga, E.
AU - Itoh, T.
N1 - Funding Information:
Supported by gran ts-in-aid Scientific Research A ( 1993,# 05770125 and 1994, #06770130) from the Ministry of Education, Science and Culture, Japan. Accepted for publication Sept. 7, 1995. Reprint requests: Takahiro Yamada, MD, Departmem of Emergency Medicine, Saga Medical School, Nabeshima 5-1-1,S aga 849, Japan. Copyright 9 1996 by Mosby-YearB ook, Inc. 00396060/96/$5.00 + 0 11/56/69461
PY - 1996
Y1 - 1996
N2 - Background. This study shows increased infiltration of mast cells in the walls of varicose veins in the lower limbs as an explanation of the pathogenesis of varix formation. Methods. Great saphenous veins exhibiting varicosity were histologically examined after vein stripping surgery and the numbers of mast cells in the varicose lesions were estimated in 20 high- power fields (x400). Normal-looking regions of the veins were referred to as controls, and normal saphenous veins were prepared during coronary artery bypass grafting and designated baseline controls. Results. The varicose lesions showed a greater extent of mast cell infiltration (15.0 ± 8.4 cells; mean ± standard deviation), whereas control veins (5.9 ± 4.0) and baseline control veins (4.4 ± 2.9) had a smaller number mast cells. Conclusions. The study suggests that increased must cell infiltration contributes to the development of varicose veins.
AB - Background. This study shows increased infiltration of mast cells in the walls of varicose veins in the lower limbs as an explanation of the pathogenesis of varix formation. Methods. Great saphenous veins exhibiting varicosity were histologically examined after vein stripping surgery and the numbers of mast cells in the varicose lesions were estimated in 20 high- power fields (x400). Normal-looking regions of the veins were referred to as controls, and normal saphenous veins were prepared during coronary artery bypass grafting and designated baseline controls. Results. The varicose lesions showed a greater extent of mast cell infiltration (15.0 ± 8.4 cells; mean ± standard deviation), whereas control veins (5.9 ± 4.0) and baseline control veins (4.4 ± 2.9) had a smaller number mast cells. Conclusions. The study suggests that increased must cell infiltration contributes to the development of varicose veins.
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U2 - 10.1016/S0039-6060(96)80256-X
DO - 10.1016/S0039-6060(96)80256-X
M3 - Article
C2 - 8619202
AN - SCOPUS:0030007046
VL - 119
SP - 494
EP - 497
JO - Surgery (United States)
JF - Surgery (United States)
SN - 0039-6060
IS - 5
ER -