Increased excretion of 3-hydroxyisovaleric acid provides evidence of biotin deficiency during pregnancy

D. M. Mock, N. I. Mock, S. L. Stratton, G. M. Heird, Diane Stadler

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In animals, subclinical biotin deficiency causes increased fetal malformations and mortality. We examined biotin nutritional status during pregnancy by measuring urinary excretion of biotin, bisnorbiotin (BNB), and 3-hydroxyisovaleric acid (3-HIA). Increased excretion of BNB, a biotin metabolite, is an indicator of increased biotin breakdown. Increased excretion of 3-HIA, an organic acid, reflects a decrease in biotin at the tissue level. In a cross-sectional design, we obtained untimed urine samples from women during either early (17±1 wk, n=13) or late (36±1 wk, n=13) pregnancy. 3-HIA (μmol/mg creatinine) was increased in both early and late pregnancy relative to control urine obtained from nonpregnant women (p

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

biotin
Biotin
excretion
pregnancy
Pregnancy
acids
Urine
urine
Fetal Mortality
Nutritional Status
Organic acids
Metabolites
Biotin deficiency
beta-hydroxyisovaleric acid
Creatinine
creatinine
organic acids and salts
nutritional status
Animals
Acids

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Increased excretion of 3-hydroxyisovaleric acid provides evidence of biotin deficiency during pregnancy. / Mock, D. M.; Mock, N. I.; Stratton, S. L.; Heird, G. M.; Stadler, Diane.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Mock, D. M. ; Mock, N. I. ; Stratton, S. L. ; Heird, G. M. ; Stadler, Diane. / Increased excretion of 3-hydroxyisovaleric acid provides evidence of biotin deficiency during pregnancy. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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AU - Stadler, Diane

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