Increased CSF E-selectin in clinical Alzheimer's disease without altered CSF Aβ42 and tau

Ge Li, Kangping Xiong, Ane Korff, Catherine Pan, Joseph Quinn, Douglas R. Galasko, Chunfeng Liu, Thomas J. Montine, Elaine R. Peskind, Jing Zhang

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Abstract

Clinically diagnosed Alzheimer's disease (AD) is pathologically heterogeneous. In this multicenter cohort of 215 clinically diagnosed AD patients and 249 controls, E-selectin and vascular cell adhesion molecule 1 (VACM-1) were measured along with amyloid-β peptide 1-42 (Aβ42) and tau.We discovered that E-selectin, a biomarker of endothelial function/vascular injury, was inversely correlated with cerebrospinal fluid (CSF) tau/Aβ42 ratio and significantly elevated in clinical AD patients without the typical AD CSF biomarker signature (i.e., low tau/Aβ42 ratio) compared to those with the signature. These findings suggest that E-selectin may be an objective biomarker related to vascular mechanisms contributing to dementia.

Original languageEnglish (US)
Pages (from-to)883-887
Number of pages5
JournalJournal of Alzheimer's Disease
Volume47
Issue number4
DOIs
StatePublished - Aug 11 2015

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Li, G., Xiong, K., Korff, A., Pan, C., Quinn, J., Galasko, D. R., Liu, C., Montine, T. J., Peskind, E. R., & Zhang, J. (2015). Increased CSF E-selectin in clinical Alzheimer's disease without altered CSF Aβ42 and tau. Journal of Alzheimer's Disease, 47(4), 883-887. https://doi.org/10.3233/JAD-150420