Increased coronary blood flow signals growth of coronary resistance vessels in near-term ovine fetuses

D. Wothe, Alan (Roger) Hohimer, M. Morton, Kent Thornburg, George Giraud, Lowell Davis

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16 Citations (Scopus)

Abstract

We measured maximal coronary artery conductance in near-term fetal sheep before and after chronic infusion with adenosine to determine whether an increase in coronary flow without hypoxemia results in increased coronary vascular growth. Adenosine was infused into the circumflex coronary artery for 12 h each day for 4 days. Coronary flow was maintained at double the resting level by regulating the infusion of adenosine via a computerized servocontrol device signaled by a Doppler flow-velocity sensor. Total arterial hemoglobin, oxygen content, and hemodynamics were unchanged. Resting circumflex coronary blood flow increased from control of 250 ± 111 to 530 ± 216 ml · min-1 · 100 g left ventricle1 with adenosine on day 1 and from 194 ± 74 to 878 ± 210 ml · min-1. · 100 g left ventricle-1 with adenosine on the last day (P <0.01). Coronary conductance, determined during maximal vasodilation, increased from 14.0 ± 5.0 to 26.9 ± 3.9 ml · min-1 · 100 g-1 · mmHg-1 over the 4 days (P <0.001). Coronary flow reserve, the difference between resting and maximal myocardial blood flow interpolated at 40 mmHg, increased from 299 ± 196 to 672 ± 266 ml · min-1 · 100 g-1 (P <0.001). Maximal coronary conductance was unchanged in control saline-infused fetuses (18.5 ± 5.1 vs. 18.5 ± 8.7 ml · min-1 · 100 g-1 · mmHg-1). We conclude that chronic intracoronary adenosine administration to the fetal myocardium modulates coronary vascular growth, even in the absence of tissue hypoxia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume282
Issue number1 51-1
StatePublished - 2002

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Adenosine
Sheep
Coronary Vessels
Fetus
Growth
Blood Vessels
Vasodilation
Heart Ventricles
Myocardium
Hemoglobins
Hemodynamics
Oxygen
Equipment and Supplies
Hypoxia

Keywords

  • Coronary conductance
  • Fetal
  • Vascular growth

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "We measured maximal coronary artery conductance in near-term fetal sheep before and after chronic infusion with adenosine to determine whether an increase in coronary flow without hypoxemia results in increased coronary vascular growth. Adenosine was infused into the circumflex coronary artery for 12 h each day for 4 days. Coronary flow was maintained at double the resting level by regulating the infusion of adenosine via a computerized servocontrol device signaled by a Doppler flow-velocity sensor. Total arterial hemoglobin, oxygen content, and hemodynamics were unchanged. Resting circumflex coronary blood flow increased from control of 250 ± 111 to 530 ± 216 ml · min-1 · 100 g left ventricle1 with adenosine on day 1 and from 194 ± 74 to 878 ± 210 ml · min-1. · 100 g left ventricle-1 with adenosine on the last day (P <0.01). Coronary conductance, determined during maximal vasodilation, increased from 14.0 ± 5.0 to 26.9 ± 3.9 ml · min-1 · 100 g-1 · mmHg-1 over the 4 days (P <0.001). Coronary flow reserve, the difference between resting and maximal myocardial blood flow interpolated at 40 mmHg, increased from 299 ± 196 to 672 ± 266 ml · min-1 · 100 g-1 (P <0.001). Maximal coronary conductance was unchanged in control saline-infused fetuses (18.5 ± 5.1 vs. 18.5 ± 8.7 ml · min-1 · 100 g-1 · mmHg-1). We conclude that chronic intracoronary adenosine administration to the fetal myocardium modulates coronary vascular growth, even in the absence of tissue hypoxia.",
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T1 - Increased coronary blood flow signals growth of coronary resistance vessels in near-term ovine fetuses

AU - Wothe, D.

AU - Hohimer, Alan (Roger)

AU - Morton, M.

AU - Thornburg, Kent

AU - Giraud, George

AU - Davis, Lowell

PY - 2002

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N2 - We measured maximal coronary artery conductance in near-term fetal sheep before and after chronic infusion with adenosine to determine whether an increase in coronary flow without hypoxemia results in increased coronary vascular growth. Adenosine was infused into the circumflex coronary artery for 12 h each day for 4 days. Coronary flow was maintained at double the resting level by regulating the infusion of adenosine via a computerized servocontrol device signaled by a Doppler flow-velocity sensor. Total arterial hemoglobin, oxygen content, and hemodynamics were unchanged. Resting circumflex coronary blood flow increased from control of 250 ± 111 to 530 ± 216 ml · min-1 · 100 g left ventricle1 with adenosine on day 1 and from 194 ± 74 to 878 ± 210 ml · min-1. · 100 g left ventricle-1 with adenosine on the last day (P <0.01). Coronary conductance, determined during maximal vasodilation, increased from 14.0 ± 5.0 to 26.9 ± 3.9 ml · min-1 · 100 g-1 · mmHg-1 over the 4 days (P <0.001). Coronary flow reserve, the difference between resting and maximal myocardial blood flow interpolated at 40 mmHg, increased from 299 ± 196 to 672 ± 266 ml · min-1 · 100 g-1 (P <0.001). Maximal coronary conductance was unchanged in control saline-infused fetuses (18.5 ± 5.1 vs. 18.5 ± 8.7 ml · min-1 · 100 g-1 · mmHg-1). We conclude that chronic intracoronary adenosine administration to the fetal myocardium modulates coronary vascular growth, even in the absence of tissue hypoxia.

AB - We measured maximal coronary artery conductance in near-term fetal sheep before and after chronic infusion with adenosine to determine whether an increase in coronary flow without hypoxemia results in increased coronary vascular growth. Adenosine was infused into the circumflex coronary artery for 12 h each day for 4 days. Coronary flow was maintained at double the resting level by regulating the infusion of adenosine via a computerized servocontrol device signaled by a Doppler flow-velocity sensor. Total arterial hemoglobin, oxygen content, and hemodynamics were unchanged. Resting circumflex coronary blood flow increased from control of 250 ± 111 to 530 ± 216 ml · min-1 · 100 g left ventricle1 with adenosine on day 1 and from 194 ± 74 to 878 ± 210 ml · min-1. · 100 g left ventricle-1 with adenosine on the last day (P <0.01). Coronary conductance, determined during maximal vasodilation, increased from 14.0 ± 5.0 to 26.9 ± 3.9 ml · min-1 · 100 g-1 · mmHg-1 over the 4 days (P <0.001). Coronary flow reserve, the difference between resting and maximal myocardial blood flow interpolated at 40 mmHg, increased from 299 ± 196 to 672 ± 266 ml · min-1 · 100 g-1 (P <0.001). Maximal coronary conductance was unchanged in control saline-infused fetuses (18.5 ± 5.1 vs. 18.5 ± 8.7 ml · min-1 · 100 g-1 · mmHg-1). We conclude that chronic intracoronary adenosine administration to the fetal myocardium modulates coronary vascular growth, even in the absence of tissue hypoxia.

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