Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

Sergio Fazio, Vladimir R. Babaev, Alisa B. Murray, Alyssa H. Hasty, Kathy J. Carter, Linda A. Gleaves, James B. Atkinson, Macrae F. Linton

    Research output: Contribution to journalArticle

    237 Scopus citations

    Abstract

    Macrophage-derived foam cells express apolipoprotein E (apoE) abundantly in atheroscleratic lesions. To examine the physiologic role of apoe secretion by the macrophage in atherogenesis, bone marrow transplantation was used to reconstitute C57bl/6 mice with macrophages that were either null or wild type for the apoE gene. After 13 weeks on an atherogenic diet, C57bl/6 mice reconstituted with apoE null marrow developed 10-fold more atherosclerosis than controls in the absence of significant differences in serum cholesterol levels or lipoprotein profiles. ApoE expression was absent in the macrophage- derived foam cells of C57bl/6 mice reconstituted with apoE null marrow. Thus, lack of apoE expression by the macrophage promotes foam cell formation. These data support a protective role for apoE expression by the macrophage in early atherogenesis.

    Original languageEnglish (US)
    Pages (from-to)4647-4652
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume94
    Issue number9
    DOIs
    StatePublished - Apr 29 1997

    ASJC Scopus subject areas

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