Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

Sergio Fazio, Vladimir R. Babaev, Alisa B. Murray, Alyssa H. Hasty, Kathy J. Carter, Linda A. Gleaves, James B. Atkinson, Macrae F. Linton

Research output: Contribution to journalArticlepeer-review

248 Scopus citations

Abstract

Macrophage-derived foam cells express apolipoprotein E (apoE) abundantly in atheroscleratic lesions. To examine the physiologic role of apoe secretion by the macrophage in atherogenesis, bone marrow transplantation was used to reconstitute C57bl/6 mice with macrophages that were either null or wild type for the apoE gene. After 13 weeks on an atherogenic diet, C57bl/6 mice reconstituted with apoE null marrow developed 10-fold more atherosclerosis than controls in the absence of significant differences in serum cholesterol levels or lipoprotein profiles. ApoE expression was absent in the macrophage- derived foam cells of C57bl/6 mice reconstituted with apoE null marrow. Thus, lack of apoE expression by the macrophage promotes foam cell formation. These data support a protective role for apoE expression by the macrophage in early atherogenesis.

Original languageEnglish (US)
Pages (from-to)4647-4652
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number9
DOIs
StatePublished - Apr 29 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

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