@article{19b8940254c2413fbe37eea5a848a0a1,
title = "Increased arabinitol levels in experimental candidiasis in rats: Arabinitol appearance rates, arabinitol/creatinine ratios, and severity of infection",
abstract = "Renal colony counts, total arabinitol appearance, and the arabinitol/creatinine ratios in the serum and urine of rats with lethal candidiasis were measured. Total arabinitol appearance and the arabinitol/creatinine ratios increased significantly after infection. The serum arabinitol/creatinine ratio was high (2 SD above the mean value in normal animals) in five of six infected rats at 24 hr, in eight of eight at 48 hr, and in none of the control animals. The urinary arabinitol/creatinine ratio was high in 14 of 19 infected rats by 24 hr, in 11 of 11 by 48 hr, and in none of the control animals. Total arabinitol appearance and the arabinitol/creatinine ratios were highly correlated with renal colony counts. Arabinitol production in vitro was sufficient to account for the increased arabinitol appearance observed in vivo in 12 of 14 rats. Thus it is concluded that the excess arabinitol that appeared in vivo was produced by the infecting fungus and that arabinitol is a quantitative marker substance for candidiasis.",
author = "B. Wong and Bernard, {E. M.} and Gold, {J. W.M.} and D. Fong and A. Silber and D. Armstrong",
note = "Funding Information: Received for publication December 14, 1981, and in revised form April 26, 1982. This work was presented in part at the 21st lnterscience Conference on Antimicrobial Agents and Chemotherapy, held in Chicago, Illinois, on November 4-6, 1981. Dr. Gold was the recipient of Junior Faculty Clinical Fellowship no. 555 from the American Cancer Society. We thank Drs. David Brigati and Philip Lieberman for help in reviewing the pathologic sections; Dr. Edward Balish for the gift of Candida albicans strain B311; Jeanette Talavera, Joanne Gedney, and the staff of the Renal-Physiology Laboratory, Memorial Hospital, for technical assistance; and Linda Lynn for manuscript preparation. Please address requests for reprints to Dr. B. Wong, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. * Present address: Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.",
year = "1982",
doi = "10.1093/infdis/146.3.346",
language = "English (US)",
volume = "146",
pages = "346--352",
journal = "Unknown Journal",
issn = "0973-3698",
publisher = "Elsevier (Singapore) Pte Ltd",
number = "3",
}