Increased arabinitol levels in experimental candidiasis in rats

Arabinitol appearance rates, arabinitol/creatinine ratios, and severity of infection

Brian Wong, E. M. Bernard, J. W M Gold, D. Fong, A. Silber, D. Armstrong

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Renal colony counts, total arabinitol appearance, and the arabinitol/creatinine ratios in the serum and urine of rats with lethal candidiasis were measured. Total arabinitol appearance and the arabinitol/creatinine ratios increased significantly after infection. The serum arabinitol/creatinine ratio was high (2 SD above the mean value in normal animals) in five of six infected rats at 24 hr, in eight of eight at 48 hr, and in none of the control animals. The urinary arabinitol/creatinine ratio was high in 14 of 19 infected rats by 24 hr, in 11 of 11 by 48 hr, and in none of the control animals. Total arabinitol appearance and the arabinitol/creatinine ratios were highly correlated with renal colony counts. Arabinitol production in vitro was sufficient to account for the increased arabinitol appearance observed in vivo in 12 of 14 rats. Thus it is concluded that the excess arabinitol that appeared in vivo was produced by the infecting fungus and that arabinitol is a quantitative marker substance for candidiasis.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalJournal of Infectious Diseases
Volume146
Issue number3
StatePublished - 1982
Externally publishedYes

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Candidiasis
Creatinine
Infection
Kidney
Serum
Reference Values
Fungi
Urine

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Increased arabinitol levels in experimental candidiasis in rats : Arabinitol appearance rates, arabinitol/creatinine ratios, and severity of infection. / Wong, Brian; Bernard, E. M.; Gold, J. W M; Fong, D.; Silber, A.; Armstrong, D.

In: Journal of Infectious Diseases, Vol. 146, No. 3, 1982, p. 346-352.

Research output: Contribution to journalArticle

Wong, Brian ; Bernard, E. M. ; Gold, J. W M ; Fong, D. ; Silber, A. ; Armstrong, D. / Increased arabinitol levels in experimental candidiasis in rats : Arabinitol appearance rates, arabinitol/creatinine ratios, and severity of infection. In: Journal of Infectious Diseases. 1982 ; Vol. 146, No. 3. pp. 346-352.
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abstract = "Renal colony counts, total arabinitol appearance, and the arabinitol/creatinine ratios in the serum and urine of rats with lethal candidiasis were measured. Total arabinitol appearance and the arabinitol/creatinine ratios increased significantly after infection. The serum arabinitol/creatinine ratio was high (2 SD above the mean value in normal animals) in five of six infected rats at 24 hr, in eight of eight at 48 hr, and in none of the control animals. The urinary arabinitol/creatinine ratio was high in 14 of 19 infected rats by 24 hr, in 11 of 11 by 48 hr, and in none of the control animals. Total arabinitol appearance and the arabinitol/creatinine ratios were highly correlated with renal colony counts. Arabinitol production in vitro was sufficient to account for the increased arabinitol appearance observed in vivo in 12 of 14 rats. Thus it is concluded that the excess arabinitol that appeared in vivo was produced by the infecting fungus and that arabinitol is a quantitative marker substance for candidiasis.",
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