Increased abundance of opioid receptor heteromers after chronic morphine administration

Achla Gupta; Jan Mulder; Ivone Gomes; Raphael Rozenfeld; Ittai Bushlin; Edmund Ong; Maribel Lim; Emeline Maillet; Mats Junek; Catherine M. Cahill; Tibor Harkany; Lakshmi A. Devi

doi:10.1126/scisignal.2000807

Increased abundance of opioid receptor heteromers after chronic morphine administration

Achla Gupta, Jan Mulder, Ivone Gomes, Raphael Rozenfeld, Ittai Bushlin, Edmund Ong, Maribel Lim, Emeline Maillet, Mats Junek, Catherine M. Cahill, Tibor Harkany, Lakshmi A. Devi

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

The μ and δ types of opioid receptors form heteromers that exhibit pharmacological and functional properties distinct from those of homomeric receptors. To characterize these complexes in the brain, we generated antibodies that selectively recognize the μ-δ heteromer and blocked its in vitro signaling. With these antibodies, we showed that chronic, but not acute, morphine treatment caused an increase in the abundance of μ-δ heteromers in key areas of the central nervous system that are implicated in pain processing. Because of its distinct signaling properties, the μ-δ heteromer could be a therapeutic target in the treatment of chronic pain and addiction.

Original language	English (US)
Pages (from-to)	ra54
Journal	Science signaling
Volume	3
Issue number	131
DOIs	https://doi.org/10.1126/scisignal.2000807
State	Published - Jul 20 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1126/scisignal.2000807

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AU - Gupta, Achla

AU - Mulder, Jan

AU - Gomes, Ivone

AU - Rozenfeld, Raphael

AU - Bushlin, Ittai

AU - Ong, Edmund

AU - Lim, Maribel

AU - Maillet, Emeline

AU - Junek, Mats

AU - Cahill, Catherine M.

AU - Harkany, Tibor

AU - Devi, Lakshmi A.

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AB - The μ and δ types of opioid receptors form heteromers that exhibit pharmacological and functional properties distinct from those of homomeric receptors. To characterize these complexes in the brain, we generated antibodies that selectively recognize the μ-δ heteromer and blocked its in vitro signaling. With these antibodies, we showed that chronic, but not acute, morphine treatment caused an increase in the abundance of μ-δ heteromers in key areas of the central nervous system that are implicated in pain processing. Because of its distinct signaling properties, the μ-δ heteromer could be a therapeutic target in the treatment of chronic pain and addiction.

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Increased abundance of opioid receptor heteromers after chronic morphine administration

Abstract

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