TY - JOUR
T1 - Increased abundance of opioid receptor heteromers after chronic morphine administration
AU - Gupta, Achla
AU - Mulder, Jan
AU - Gomes, Ivone
AU - Rozenfeld, Raphael
AU - Bushlin, Ittai
AU - Ong, Edmund
AU - Lim, Maribel
AU - Maillet, Emeline
AU - Junek, Mats
AU - Cahill, Catherine M.
AU - Harkany, Tibor
AU - Devi, Lakshmi A.
PY - 2010/7/20
Y1 - 2010/7/20
N2 - The μ and δ types of opioid receptors form heteromers that exhibit pharmacological and functional properties distinct from those of homomeric receptors. To characterize these complexes in the brain, we generated antibodies that selectively recognize the μ-δ heteromer and blocked its in vitro signaling. With these antibodies, we showed that chronic, but not acute, morphine treatment caused an increase in the abundance of μ-δ heteromers in key areas of the central nervous system that are implicated in pain processing. Because of its distinct signaling properties, the μ-δ heteromer could be a therapeutic target in the treatment of chronic pain and addiction.
AB - The μ and δ types of opioid receptors form heteromers that exhibit pharmacological and functional properties distinct from those of homomeric receptors. To characterize these complexes in the brain, we generated antibodies that selectively recognize the μ-δ heteromer and blocked its in vitro signaling. With these antibodies, we showed that chronic, but not acute, morphine treatment caused an increase in the abundance of μ-δ heteromers in key areas of the central nervous system that are implicated in pain processing. Because of its distinct signaling properties, the μ-δ heteromer could be a therapeutic target in the treatment of chronic pain and addiction.
UR - http://www.scopus.com/inward/record.url?scp=77956635370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956635370&partnerID=8YFLogxK
U2 - 10.1126/scisignal.2000807
DO - 10.1126/scisignal.2000807
M3 - Article
C2 - 20647592
AN - SCOPUS:77956635370
VL - 3
SP - ra54
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
SN - 1937-9145
IS - 131
ER -