Increase of serum interleukin 2 receptor level in thermally injured patients

Julita A. Teodorczyk-Injeyan; Brian G. Sparkes; Gordon B. Mills; Rudolf E. Falk; Walter J. Peters

doi:10.1016/0090-1229(89)90020-2

Increase of serum interleukin 2 receptor level in thermally injured patients

Julita A. Teodorczyk-Injeyan, Brian G. Sparkes, Gordon B. Mills, Rudolf E. Falk, Walter J. Peters

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Serum concentrations of receptor for the T cell growth factor interleukin 2 (IL-2R) were compared to the capacity of activated T cells to express surface IL-2R in patients with major burns. In immunosuppressed patients the numbers of cells expressing IL-2R were transiently (survivors) or permanently (nonsurvivors) reduced (up to 50 and 90%, respectively). In contrast, the levels of soluble IL-2R in patients' sera were significantly (P < 0.001-0.05) elevated throughout the postburn period. Within 24 hr postinjury, over 90% of patients demonstrated 400-3500 U/ml of serum IL-2R compared with 120-340 U/ml in normal controls. Soluble IL-2R, when patients became immunosuppressed, further increased to 4445 ± 962 U/ml in nonsurvivors and to 2031 ± 578 U/ml in survivors, and demonstrated a significant capacity to inhibit the activity of exogenous IL-2. In survivors the levels of serum IL-2R declined at discharge, to 1009 ± 104 U/ml. Thus, in thermally injured patients, soluble IL-2 receptor concentrations are elevated, and could interfere with IL-2-mediated immune interactions.

Original language	English (US)
Pages (from-to)	205-215
Number of pages	11
Journal	Clinical Immunology and Immunopathology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(89)90020-2
State	Published - May 1989
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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title = "Increase of serum interleukin 2 receptor level in thermally injured patients",

abstract = "Serum concentrations of receptor for the T cell growth factor interleukin 2 (IL-2R) were compared to the capacity of activated T cells to express surface IL-2R in patients with major burns. In immunosuppressed patients the numbers of cells expressing IL-2R were transiently (survivors) or permanently (nonsurvivors) reduced (up to 50 and 90%, respectively). In contrast, the levels of soluble IL-2R in patients' sera were significantly (P < 0.001-0.05) elevated throughout the postburn period. Within 24 hr postinjury, over 90% of patients demonstrated 400-3500 U/ml of serum IL-2R compared with 120-340 U/ml in normal controls. Soluble IL-2R, when patients became immunosuppressed, further increased to 4445 ± 962 U/ml in nonsurvivors and to 2031 ± 578 U/ml in survivors, and demonstrated a significant capacity to inhibit the activity of exogenous IL-2. In survivors the levels of serum IL-2R declined at discharge, to 1009 ± 104 U/ml. Thus, in thermally injured patients, soluble IL-2 receptor concentrations are elevated, and could interfere with IL-2-mediated immune interactions.",

author = "Teodorczyk-Injeyan, {Julita A.} and Sparkes, {Brian G.} and Mills, {Gordon B.} and Falk, {Rudolf E.} and Peters, {Walter J.}",

note = "Funding Information: {\textquoteright} Supported by the Defence & Civil Institute of Environmental Medicine (Contract OISE.W7711-6-9052) and in part by the MRC of Canada Grant MA-8770 for flow cytometry. {\textquoteright} To whom correspondence should be addressed. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Teodorczyk-Injeyan, Julita A.

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AU - Mills, Gordon B.

AU - Falk, Rudolf E.

AU - Peters, Walter J.

N1 - Funding Information: ’ Supported by the Defence & Civil Institute of Environmental Medicine (Contract OISE.W7711-6-9052) and in part by the MRC of Canada Grant MA-8770 for flow cytometry. ’ To whom correspondence should be addressed. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1989/5

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N2 - Serum concentrations of receptor for the T cell growth factor interleukin 2 (IL-2R) were compared to the capacity of activated T cells to express surface IL-2R in patients with major burns. In immunosuppressed patients the numbers of cells expressing IL-2R were transiently (survivors) or permanently (nonsurvivors) reduced (up to 50 and 90%, respectively). In contrast, the levels of soluble IL-2R in patients' sera were significantly (P < 0.001-0.05) elevated throughout the postburn period. Within 24 hr postinjury, over 90% of patients demonstrated 400-3500 U/ml of serum IL-2R compared with 120-340 U/ml in normal controls. Soluble IL-2R, when patients became immunosuppressed, further increased to 4445 ± 962 U/ml in nonsurvivors and to 2031 ± 578 U/ml in survivors, and demonstrated a significant capacity to inhibit the activity of exogenous IL-2. In survivors the levels of serum IL-2R declined at discharge, to 1009 ± 104 U/ml. Thus, in thermally injured patients, soluble IL-2 receptor concentrations are elevated, and could interfere with IL-2-mediated immune interactions.

AB - Serum concentrations of receptor for the T cell growth factor interleukin 2 (IL-2R) were compared to the capacity of activated T cells to express surface IL-2R in patients with major burns. In immunosuppressed patients the numbers of cells expressing IL-2R were transiently (survivors) or permanently (nonsurvivors) reduced (up to 50 and 90%, respectively). In contrast, the levels of soluble IL-2R in patients' sera were significantly (P < 0.001-0.05) elevated throughout the postburn period. Within 24 hr postinjury, over 90% of patients demonstrated 400-3500 U/ml of serum IL-2R compared with 120-340 U/ml in normal controls. Soluble IL-2R, when patients became immunosuppressed, further increased to 4445 ± 962 U/ml in nonsurvivors and to 2031 ± 578 U/ml in survivors, and demonstrated a significant capacity to inhibit the activity of exogenous IL-2. In survivors the levels of serum IL-2R declined at discharge, to 1009 ± 104 U/ml. Thus, in thermally injured patients, soluble IL-2 receptor concentrations are elevated, and could interfere with IL-2-mediated immune interactions.

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Increase of serum interleukin 2 receptor level in thermally injured patients

Abstract

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