TY - JOUR
T1 - Increase of serum interleukin 2 receptor level in thermally injured patients
AU - Teodorczyk-Injeyan, Julita A.
AU - Sparkes, Brian G.
AU - Mills, Gordon B.
AU - Falk, Rudolf E.
AU - Peters, Walter J.
N1 - Funding Information:
’ Supported by the Defence & Civil Institute of Environmental Medicine (Contract OISE.W7711-6-9052) and in part by the MRC of Canada Grant MA-8770 for flow cytometry. ’ To whom correspondence should be addressed.
PY - 1989/5
Y1 - 1989/5
N2 - Serum concentrations of receptor for the T cell growth factor interleukin 2 (IL-2R) were compared to the capacity of activated T cells to express surface IL-2R in patients with major burns. In immunosuppressed patients the numbers of cells expressing IL-2R were transiently (survivors) or permanently (nonsurvivors) reduced (up to 50 and 90%, respectively). In contrast, the levels of soluble IL-2R in patients' sera were significantly (P < 0.001-0.05) elevated throughout the postburn period. Within 24 hr postinjury, over 90% of patients demonstrated 400-3500 U/ml of serum IL-2R compared with 120-340 U/ml in normal controls. Soluble IL-2R, when patients became immunosuppressed, further increased to 4445 ± 962 U/ml in nonsurvivors and to 2031 ± 578 U/ml in survivors, and demonstrated a significant capacity to inhibit the activity of exogenous IL-2. In survivors the levels of serum IL-2R declined at discharge, to 1009 ± 104 U/ml. Thus, in thermally injured patients, soluble IL-2 receptor concentrations are elevated, and could interfere with IL-2-mediated immune interactions.
AB - Serum concentrations of receptor for the T cell growth factor interleukin 2 (IL-2R) were compared to the capacity of activated T cells to express surface IL-2R in patients with major burns. In immunosuppressed patients the numbers of cells expressing IL-2R were transiently (survivors) or permanently (nonsurvivors) reduced (up to 50 and 90%, respectively). In contrast, the levels of soluble IL-2R in patients' sera were significantly (P < 0.001-0.05) elevated throughout the postburn period. Within 24 hr postinjury, over 90% of patients demonstrated 400-3500 U/ml of serum IL-2R compared with 120-340 U/ml in normal controls. Soluble IL-2R, when patients became immunosuppressed, further increased to 4445 ± 962 U/ml in nonsurvivors and to 2031 ± 578 U/ml in survivors, and demonstrated a significant capacity to inhibit the activity of exogenous IL-2. In survivors the levels of serum IL-2R declined at discharge, to 1009 ± 104 U/ml. Thus, in thermally injured patients, soluble IL-2 receptor concentrations are elevated, and could interfere with IL-2-mediated immune interactions.
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U2 - 10.1016/0090-1229(89)90020-2
DO - 10.1016/0090-1229(89)90020-2
M3 - Article
C2 - 2784753
AN - SCOPUS:0024543687
SN - 0090-1229
VL - 51
SP - 205
EP - 215
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -