TY - JOUR
T1 - Increase in liver and kidney deoxycytidine kinase activity linked to neoplastic transformation
AU - Harkrader, Ronald J.
AU - Jackson, Robert C.
AU - Ross, Donald A.
AU - Weber, George
PY - 1980
Y1 - 1980
N2 - Deoxycytidine kinase activity in normal rat liver cytosol was low (0.8 nmol/hr/mg protein); it increased 2–26-fold in 12 lines of chemically-induced, transplantable rat hepatomas of different growth rates. The increased kinase activity correlated positively with the hepatoma growth rate. The kinase activity did not change in the regenerating liver and the activity in the differentiating, neonatal rat liver was similar to values in adult liver. Deoxycytidine kinase activity in 2 chemically-induced, transplantable rat kidney tumors was increased to twice the value found in normal renal cortex. Among 15 normal rat tissues examined the highest kinase activities were observed in thymus, bone marrow and spleen. Of the normal and malignant rat tissues tested, only testis had detectable cytidine deaminase activity.
AB - Deoxycytidine kinase activity in normal rat liver cytosol was low (0.8 nmol/hr/mg protein); it increased 2–26-fold in 12 lines of chemically-induced, transplantable rat hepatomas of different growth rates. The increased kinase activity correlated positively with the hepatoma growth rate. The kinase activity did not change in the regenerating liver and the activity in the differentiating, neonatal rat liver was similar to values in adult liver. Deoxycytidine kinase activity in 2 chemically-induced, transplantable rat kidney tumors was increased to twice the value found in normal renal cortex. Among 15 normal rat tissues examined the highest kinase activities were observed in thymus, bone marrow and spleen. Of the normal and malignant rat tissues tested, only testis had detectable cytidine deaminase activity.
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U2 - 10.1016/0006-291X(80)91361-3
DO - 10.1016/0006-291X(80)91361-3
M3 - Article
C2 - 6255949
AN - SCOPUS:0019161479
VL - 96
SP - 1633
EP - 1639
JO - Topics in Catalysis
JF - Topics in Catalysis
IS - 4
ER -