Incubation of D-phenylalanyl-L-phenylalanylglycine with peptidylglycine α-amidating monooxygenase (PAM) in the presence of 18O 2 generates the corresponding hydroxyglycyl peptide whose FAB mass spectrum shows high incorporation of 18O into the hydroxy group; this suggests that the mechanism may involve direct hydroxylation of carbon.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Molecular Medicine