Incorporating information about cost-effectiveness into evidence-based decision-making: The evidence-based practice center (EPC) model

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Rationale: There is a pressing need for guidance on how to incorporate economic information into evidence-based decision-making. Such guidance should take account of the quality and relevance of economic evaluations. Objective: To summarize lessons learned in integrating information from decision analyses and cost-effectiveness analyses. Key Issues: Several methods used by the Evidence-Based Practice Centers (EPCs) to conduct systematic reviews are applicable to assessing economic studies. We discuss methods to identify key questions for the review of economic studies. Reviews should assess how an economic model incorporates clinical logic and handles uncertainty about effectiveness. As is the case for metaanalysis of interventions, qualitative or quantitative synthesis of economic studies should explore heterogeneity to identify key uncertainties underlying divergent results as well as unsuspected sources of bias. Conclusions: Applying EPC methods to synthesis of economic information can increase their relevance to clinicians and policy-makers and inform decisions that require tradeoffs between effectiveness and harms of interventions.

Original languageEnglish (US)
Pages (from-to)II33-II43
JournalMedical care
Volume43
Issue number7 SUPPL.
StatePublished - Jul 1 2005

Keywords

  • Cost effectiveness
  • Decision making
  • Evidence-based medicine

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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