Incomplete coronary vasodilation during myocardial ischemia in swine.

George Pantely, J. D. Bristow, L. J. Swenson, H. D. Ladley, W. B. Johnson, C. G. Anselone

    Research output: Contribution to journalArticle

    55 Citations (Scopus)

    Abstract

    To determine if endogenous (ENDG) vasodilation was maximum during myocardial ischemia, left anterior descending (LAD) mean pressure (P) was reduced for 20 min in 13 swine. At LAD P of 45 mmHg (LAD P45) flow fell during ENDG = 25 but rose to 44 ml/min during adenosine (AD) infusion (P less than 0.01). Flow increased to subendocardium (ENDG 0.65 vs. AD 1.04 ml X min-1 X g-1) and to subepicardium (ENDG 0.99 vs. AD 1.83 ml X min-1 X g-1; P less than 0.05). No significant change occurred in myocardial O2 consumption (MVO2; ENDG 2.91 vs. AD 3.18 ml X min-1 X g-1), lactate extraction (ENDG = -5 vs. AD-1%), and wall thickening (WTh; ENDG + 16 vs. AD + 17%). At LAD P35, flow during ENDG was 12 but rose to 19 ml/min during AD (P less than 0.01). Flow increased to subendocardium (ENDG 0.24 vs. AD 0.46 ml X min-1 X g-1; P less than 0.02) and subepicardium (ENDG 0.51 vs. AD 0.87 ml X min-1 X g-1; P less than 0.01). No significant change occurred in MVo2 (ENDG 1.38 vs. AD 1.59 ml/min), lactate extraction (ENDG -38 vs. AD -22%), WTh (ENDG -1 vs. AD + 1%). Thus endogenous vasodilation reserve was not used fully during ischemia. AD increased flow but did not improve abnormalities in myocardial function or metabolism.

    Original languageEnglish (US)
    JournalThe American journal of physiology
    Volume249
    Issue number3 Pt 2
    StatePublished - Sep 1985

    Fingerprint

    Vasodilation
    Adenosine
    Myocardial Ischemia
    Swine
    Lactic Acid
    Ischemia
    Pressure

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Pantely, G., Bristow, J. D., Swenson, L. J., Ladley, H. D., Johnson, W. B., & Anselone, C. G. (1985). Incomplete coronary vasodilation during myocardial ischemia in swine. The American journal of physiology, 249(3 Pt 2).

    Incomplete coronary vasodilation during myocardial ischemia in swine. / Pantely, George; Bristow, J. D.; Swenson, L. J.; Ladley, H. D.; Johnson, W. B.; Anselone, C. G.

    In: The American journal of physiology, Vol. 249, No. 3 Pt 2, 09.1985.

    Research output: Contribution to journalArticle

    Pantely, G, Bristow, JD, Swenson, LJ, Ladley, HD, Johnson, WB & Anselone, CG 1985, 'Incomplete coronary vasodilation during myocardial ischemia in swine.', The American journal of physiology, vol. 249, no. 3 Pt 2.
    Pantely G, Bristow JD, Swenson LJ, Ladley HD, Johnson WB, Anselone CG. Incomplete coronary vasodilation during myocardial ischemia in swine. The American journal of physiology. 1985 Sep;249(3 Pt 2).
    Pantely, George ; Bristow, J. D. ; Swenson, L. J. ; Ladley, H. D. ; Johnson, W. B. ; Anselone, C. G. / Incomplete coronary vasodilation during myocardial ischemia in swine. In: The American journal of physiology. 1985 ; Vol. 249, No. 3 Pt 2.
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    abstract = "To determine if endogenous (ENDG) vasodilation was maximum during myocardial ischemia, left anterior descending (LAD) mean pressure (P) was reduced for 20 min in 13 swine. At LAD P of 45 mmHg (LAD P45) flow fell during ENDG = 25 but rose to 44 ml/min during adenosine (AD) infusion (P less than 0.01). Flow increased to subendocardium (ENDG 0.65 vs. AD 1.04 ml X min-1 X g-1) and to subepicardium (ENDG 0.99 vs. AD 1.83 ml X min-1 X g-1; P less than 0.05). No significant change occurred in myocardial O2 consumption (MVO2; ENDG 2.91 vs. AD 3.18 ml X min-1 X g-1), lactate extraction (ENDG = -5 vs. AD-1{\%}), and wall thickening (WTh; ENDG + 16 vs. AD + 17{\%}). At LAD P35, flow during ENDG was 12 but rose to 19 ml/min during AD (P less than 0.01). Flow increased to subendocardium (ENDG 0.24 vs. AD 0.46 ml X min-1 X g-1; P less than 0.02) and subepicardium (ENDG 0.51 vs. AD 0.87 ml X min-1 X g-1; P less than 0.01). No significant change occurred in MVo2 (ENDG 1.38 vs. AD 1.59 ml/min), lactate extraction (ENDG -38 vs. AD -22{\%}), WTh (ENDG -1 vs. AD + 1{\%}). Thus endogenous vasodilation reserve was not used fully during ischemia. AD increased flow but did not improve abnormalities in myocardial function or metabolism.",
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    AU - Johnson, W. B.

    AU - Anselone, C. G.

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