Incomplete coronary vasodilation during myocardial ischemia in swine

G. A. Pantely, J. D. Bristow, L. J. Swenson

    Research output: Contribution to journalArticle

    55 Scopus citations

    Abstract

    To determine if endogenous (ENDG) vasodilation was maximum during myocardial ischemia, left anterior descending (LAD) mean pressure (P) was reduced for 20 min in 13 swine. At LAD P of 45 mmHg (LAD P45) flow fell during ENDG = 25 but rose to 44 ml/min during adenosine (AD) infusion (P < 0.01). Flow increased to subendocardium (ENDG 0.65 vs. AD 1.04 ml·min-1·g-1) and to subepicardium (ENDG 0.99 vs. AD 1.83 ml·min-1·g-1; P < 0.05). No significant change occurred in myocardial O2 consumption (MV̇O2; ENDG 2.91 vs AD 3.18 ml·min-1·g-1), lactate extraction (ENDG = -5 vs AD -1%), and wall thickening (WTh; ENDG +16 vs. AD +17%). At LAD P35, flow during ENDG was 12 but rose to 19 ml/min during AD (P < 0.01). Flow increased to subendocardium (ENDG 0.24 vs. AD 0.46 ml·min-1·g-1; P < 0.02) and subepicardium (ENDG 0.51 vs. AD 0.87 ml·min-1·g-1; P < 0.01). No significant change occurred in MV̇O2 (ENDG 1.38 vs. AD 1.59 ml/min), lactate extraction (ENDG -38 vs. AD -22%), WTh (ENDG -1 vs. AD +1%). Thus endogenous vasodilation reserve was not used fully during ischemia. AD increased flow but did not improve abnormalities in myocardial function or metabolism.

    Original languageEnglish (US)
    Pages (from-to)H638-H647
    JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
    Volume18
    Issue number3
    DOIs
    StatePublished - 1985

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

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