Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis

Alexander J. Neuwelt, Tam M. Nguyen, Rongwei (Rochelle) Fu, Joseph Bubalo, Rose M arie Tyson, Cynthia Lacy, Seymur Gahramanov, Morad Nasseri, Penelope D. Barnes, Edward Neuwelt

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

AIMS: Prophylaxis against Pneumocystis jiroveci pneumonia (PJP) is currently recommended for patients receiving chemoradiation with temozolomide for newly diagnosed glioblastoma multiforme. At our institution, PJP prophylaxis during temozolomide treatment has not been routinely given because of the paucity of supporting data. We investigated the rate of PJP infections in our patients.

PATIENTS & METHODS: We conducted a retrospective chart review of 240 brain tumor patients treated between 1999 and 2012 with temozolomide and no PJP prophylaxis, 127 of which received concurrent chemoradiation.

RESULTS: One in 240 patients (0.4%; 95% CI: 0.01-2.00; median total dose: 7375 mg/m(2); interquartile range: 1300) were diagnosed with PJP.

CONCLUSION: There was a

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalCNS oncology
Volume3
Issue number4
DOIs
StatePublished - Jul 1 2014
Externally publishedYes

Fingerprint

temozolomide
Pneumocystis carinii
Pneumocystis Pneumonia
Incidence
Neoplasms
Glioblastoma
Brain Neoplasms

Keywords

  • brain radiation
  • glioblastoma
  • Pneumocystis jirovecii
  • temozolomide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis. / Neuwelt, Alexander J.; Nguyen, Tam M.; Fu, Rongwei (Rochelle); Bubalo, Joseph; Tyson, Rose M arie; Lacy, Cynthia; Gahramanov, Seymur; Nasseri, Morad; Barnes, Penelope D.; Neuwelt, Edward.

In: CNS oncology, Vol. 3, No. 4, 01.07.2014, p. 267-273.

Research output: Contribution to journalArticle

Neuwelt, AJ, Nguyen, TM, Fu, RR, Bubalo, J, Tyson, RMA, Lacy, C, Gahramanov, S, Nasseri, M, Barnes, PD & Neuwelt, E 2014, 'Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis', CNS oncology, vol. 3, no. 4, pp. 267-273. https://doi.org/10.2217/cns.14.24
Neuwelt, Alexander J. ; Nguyen, Tam M. ; Fu, Rongwei (Rochelle) ; Bubalo, Joseph ; Tyson, Rose M arie ; Lacy, Cynthia ; Gahramanov, Seymur ; Nasseri, Morad ; Barnes, Penelope D. ; Neuwelt, Edward. / Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis. In: CNS oncology. 2014 ; Vol. 3, No. 4. pp. 267-273.
@article{227e2ada9b1944dbad2d056f0d0641b9,
title = "Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis",
abstract = "AIMS: Prophylaxis against Pneumocystis jiroveci pneumonia (PJP) is currently recommended for patients receiving chemoradiation with temozolomide for newly diagnosed glioblastoma multiforme. At our institution, PJP prophylaxis during temozolomide treatment has not been routinely given because of the paucity of supporting data. We investigated the rate of PJP infections in our patients.PATIENTS & METHODS: We conducted a retrospective chart review of 240 brain tumor patients treated between 1999 and 2012 with temozolomide and no PJP prophylaxis, 127 of which received concurrent chemoradiation.RESULTS: One in 240 patients (0.4{\%}; 95{\%} CI: 0.01-2.00; median total dose: 7375 mg/m(2); interquartile range: 1300) were diagnosed with PJP.CONCLUSION: There was a",
keywords = "brain radiation, glioblastoma, Pneumocystis jirovecii, temozolomide",
author = "Neuwelt, {Alexander J.} and Nguyen, {Tam M.} and Fu, {Rongwei (Rochelle)} and Joseph Bubalo and Tyson, {Rose M arie} and Cynthia Lacy and Seymur Gahramanov and Morad Nasseri and Barnes, {Penelope D.} and Edward Neuwelt",
year = "2014",
month = "7",
day = "1",
doi = "10.2217/cns.14.24",
language = "English (US)",
volume = "3",
pages = "267--273",
journal = "CNS oncology",
issn = "2045-0915",
publisher = "Future Medicine Ltd.",
number = "4",

}

TY - JOUR

T1 - Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis

AU - Neuwelt, Alexander J.

AU - Nguyen, Tam M.

AU - Fu, Rongwei (Rochelle)

AU - Bubalo, Joseph

AU - Tyson, Rose M arie

AU - Lacy, Cynthia

AU - Gahramanov, Seymur

AU - Nasseri, Morad

AU - Barnes, Penelope D.

AU - Neuwelt, Edward

PY - 2014/7/1

Y1 - 2014/7/1

N2 - AIMS: Prophylaxis against Pneumocystis jiroveci pneumonia (PJP) is currently recommended for patients receiving chemoradiation with temozolomide for newly diagnosed glioblastoma multiforme. At our institution, PJP prophylaxis during temozolomide treatment has not been routinely given because of the paucity of supporting data. We investigated the rate of PJP infections in our patients.PATIENTS & METHODS: We conducted a retrospective chart review of 240 brain tumor patients treated between 1999 and 2012 with temozolomide and no PJP prophylaxis, 127 of which received concurrent chemoradiation.RESULTS: One in 240 patients (0.4%; 95% CI: 0.01-2.00; median total dose: 7375 mg/m(2); interquartile range: 1300) were diagnosed with PJP.CONCLUSION: There was a

AB - AIMS: Prophylaxis against Pneumocystis jiroveci pneumonia (PJP) is currently recommended for patients receiving chemoradiation with temozolomide for newly diagnosed glioblastoma multiforme. At our institution, PJP prophylaxis during temozolomide treatment has not been routinely given because of the paucity of supporting data. We investigated the rate of PJP infections in our patients.PATIENTS & METHODS: We conducted a retrospective chart review of 240 brain tumor patients treated between 1999 and 2012 with temozolomide and no PJP prophylaxis, 127 of which received concurrent chemoradiation.RESULTS: One in 240 patients (0.4%; 95% CI: 0.01-2.00; median total dose: 7375 mg/m(2); interquartile range: 1300) were diagnosed with PJP.CONCLUSION: There was a

KW - brain radiation

KW - glioblastoma

KW - Pneumocystis jirovecii

KW - temozolomide

UR - http://www.scopus.com/inward/record.url?scp=84937687081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937687081&partnerID=8YFLogxK

U2 - 10.2217/cns.14.24

DO - 10.2217/cns.14.24

M3 - Article

VL - 3

SP - 267

EP - 273

JO - CNS oncology

JF - CNS oncology

SN - 2045-0915

IS - 4

ER -