Incidence of new-onset seizures in mild to moderate Alzheimer disease

Michael C. Irizarry, Shelia Jin, Feng He, Jennifer A. Emond, Rema Raman, Ronald G. Thomas, Mary Sano, Joseph Quinn, Pierre N. Tariot, Douglas R. Galasko, Lianna S. Ishihara, John G. Weil, Paul S. Aisen

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68 Scopus citations


Objective: To estimate the incidence rate and predictors of seizures in patients with mild to moderate Alzheimer disease (AD). Design: Cohort study of patients with mild to moderate AD in clinical trials. Risk factors for potential seizures were evaluated by stratified descriptive statistics and univariable and multivariable Cox proportional hazards regressions. Setting: Pooled patient-level data from 10 Alzheimer Disease Cooperative Study clinical trials in mild to moderate AD from 1995 to 2010. Patients: Three thousand seventy-eight subjects randomized to the treatment or placebo arms of 10 AD clinical trials. Screening Mini-Mental State Examination scores ranged between 10 and 28. Results: Eighteen seizures were reported in 3078 randomized subjects, with an incidence rate of 484 per 100 000 person-years (95% CI, 287-764). Statistically significant independent risk factors for seizure were younger age (adjusted hazard ratio, 0.80; 95% CI, 0.69-0.93 per every 5 years of age), greater cognitive impairment at baseline (adjusted hazard ratio, 2.79; 95% CI, 1.06-7.33 for Mini-Mental State Examination scores

Original languageEnglish (US)
Pages (from-to)368-372
Number of pages5
JournalArchives of Neurology
Issue number3
StatePublished - Mar 2012


ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Irizarry, M. C., Jin, S., He, F., Emond, J. A., Raman, R., Thomas, R. G., Sano, M., Quinn, J., Tariot, P. N., Galasko, D. R., Ishihara, L. S., Weil, J. G., & Aisen, P. S. (2012). Incidence of new-onset seizures in mild to moderate Alzheimer disease. Archives of Neurology, 69(3), 368-372.