El número y la calidad de los embriones transferidos en dí a 2 afectan la tasa de embarazos gemelares y múltiples

Translated title of the contribution: Incidence of both twins and multiple pregnancy rates when different number of embryos with different quality were transferred at day 2 Post-ICSI

I. Molina, R. P. Cervera, L. Dieguez, A. Monzó, A. Romeu

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Selection criteria of embryo quality applied at day 2 post-ICSI based on blastomere number, size and fragmentation degree, are usually poor predictors of further embryo development potential. Objective: The evaluation of the effect of the number of embryos transferred at day 2, based on their quality (morphological characteristics), on both twining and multiple pregnancy rates. Design: Retrospective study of 782 ICSI cycles (from january 2000 to may 2003) have been considered. A maximum of 4 embryos were transferred in each cycle, and at least 2 of those embryos transferred were of grades 1-2. Pregnancy, implantation and abortion rates were compared when different number of embryos were transferred. Setting: Human Reproduction Service at "La Fe" University Hospital. Results: Pregnancy rate was significantly lower when 2 embryos were transferred (2: 29% vs 3: 37% y 4: 40%; p <0.05). Moreover abortion rate was lower when more than two embryos were transferred, although these differences did not reach levels of significance (2: 21% vs 3: 19% vs 4: 18%; p>0.05). These both facts would suggest to transfer the highest number of embryos as allowed by the legislation. However, when 3 embryos were transferred, both twining (30%) and multiple (11%) pregnancy rates, although similar to that obtained by the majority of ART units, are unacceptable. Conclusions: The selection criteria of embryo quality applied at day 2 post-ICSI, only allows to discriminate and discard those degenerated or blocked embryos. Therefore, the development of new selection criteria of embryo quality at day 2 post-ICSI could reduce the number of embryos transferred without penalize pregnancy rate.

Translated title of the contributionIncidence of both twins and multiple pregnancy rates when different number of embryos with different quality were transferred at day 2 Post-ICSI
Original languageSpanish
Pages (from-to)25-31
Number of pages7
JournalRevista Iberoamericana de Fertilidad y Reproduccion Humana
Volume21
Issue number1
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Day 2 embryo transfer
  • Embryo quality
  • ICSI
  • Multiple pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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