Incidence of Alzheimer's disease in a rural community in India: The Indo-US study

V. Chandra, R. Pandav, Hiroko Dodge, J. M. Johnston, S. H. Belle, S. T. DeKosky, Mary Ganguli

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Objective: To determine overall and age-specific incidence rates of AD in a rural, population-based cohort in Ballabgarh, India, and to compare them with those of a reference US population in the Monongahela Valley of Pennsylvania. Methods: A 2-year, prospective, epidemiologic study of subjects aged ≥55 years utilizing repeated cognitive and functional ability screening, followed by standardized clinical evaluation using the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for the diagnosis, and the Clinical Dementia Rating scale for the staging, of dementia and AD. Results: Incidence rates per 1000 person-years for AD with CDR ≥0.5 were 3.24 (95% CI: 1.48-6.14) for those aged ≥65 years and 1.74 (95% CI: 0.84-3.20) for those aged ≥55 years. Standardized against the age distribution of the 1990 US Census, the overall incidence rate in those aged ≥65 years was 4.7 per 1000 person-years, substantially lower than the corresponding rate of 17.5 per 1000 person-years in the Monongahela Valley. Conclusion: These are the first AD incidence rates to be reported from the Indian subcontinent, and they appear to be among the lowest ever reported. However, the relatively short duration of follow-up, cultural factors, and other potential confounders suggest caution in interpreting this finding.

Original languageEnglish (US)
Pages (from-to)985-989
Number of pages5
JournalNeurology
Volume57
Issue number6
StatePublished - Sep 25 2001
Externally publishedYes

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Rural Population
India
Alzheimer Disease
Incidence
Dementia
National Institute of Neurological Disorders and Stroke
Communication Disorders
Aptitude
Age Distribution
Censuses
varespladib methyl
Diagnostic and Statistical Manual of Mental Disorders
Epidemiologic Studies
Prospective Studies
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chandra, V., Pandav, R., Dodge, H., Johnston, J. M., Belle, S. H., DeKosky, S. T., & Ganguli, M. (2001). Incidence of Alzheimer's disease in a rural community in India: The Indo-US study. Neurology, 57(6), 985-989.

Incidence of Alzheimer's disease in a rural community in India : The Indo-US study. / Chandra, V.; Pandav, R.; Dodge, Hiroko; Johnston, J. M.; Belle, S. H.; DeKosky, S. T.; Ganguli, Mary.

In: Neurology, Vol. 57, No. 6, 25.09.2001, p. 985-989.

Research output: Contribution to journalArticle

Chandra, V, Pandav, R, Dodge, H, Johnston, JM, Belle, SH, DeKosky, ST & Ganguli, M 2001, 'Incidence of Alzheimer's disease in a rural community in India: The Indo-US study', Neurology, vol. 57, no. 6, pp. 985-989.
Chandra V, Pandav R, Dodge H, Johnston JM, Belle SH, DeKosky ST et al. Incidence of Alzheimer's disease in a rural community in India: The Indo-US study. Neurology. 2001 Sep 25;57(6):985-989.
Chandra, V. ; Pandav, R. ; Dodge, Hiroko ; Johnston, J. M. ; Belle, S. H. ; DeKosky, S. T. ; Ganguli, Mary. / Incidence of Alzheimer's disease in a rural community in India : The Indo-US study. In: Neurology. 2001 ; Vol. 57, No. 6. pp. 985-989.
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