Incidence and source of hyperamylasemia after cardiac surgery

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the incidence and possible mechanisms of postoperative hyperamylasemia in 101 paitents after cardiac surgery. Amylase (EC 3.2.1.1) activities in serum were increased in 36% of patients after bypass surgery, 59% of patients after valve replacement, and in 69% of patients after combined bypass and valve replacement. Lipase (EC 3.1.1.3) activity was increased in 30% of all patients. We found enzymatic evidence for pancreatitis in six patients. Thirty-six patients showed increased salivary (S-type) amylase activity, with a positive correlation (r = 0.55, P <0.001) between the severity of pleural effusions and the peak S-type amylase activity. Hyperamylasemia after cardiac surgery is apparently often related to absorption of S-type amylase from pleural fluid and (or) from aspirated salivary secretions. Monitoring patients for postsurgical pancreatitis necessitates assay of amylase isoenzymes to distinguish abnormalities resulting in release of pancreatic (P-type) amylase from those involving release of S-type amylase.

Original languageEnglish (US)
Pages (from-to)916-919
Number of pages4
JournalClinical Chemistry
Volume34
Issue number5
StatePublished - 1988
Externally publishedYes

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Hyperamylasemia
Amylases
Surgery
Thoracic Surgery
Incidence
Pancreatitis
Patient monitoring
Physiologic Monitoring
Pleural Effusion
Lipase
Isoenzymes
Assays
Fluids

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Incidence and source of hyperamylasemia after cardiac surgery. / Kazmierczak, Steven (Steve); Van Lente, F.

In: Clinical Chemistry, Vol. 34, No. 5, 1988, p. 916-919.

Research output: Contribution to journalArticle

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