Abstract
Background: The significance of a contralateral breast cancer is largely unknown, making prophylactic mastectomy controversial. Methods: Differences between stages of initial and contralateral cancers were determined by t test. Survival distributions were compared by log-rank analyses and compared with Surveillance Epidemiology and End Results data for unilateral cancers. Results: Metachronous contralateral cancers occurred at a rate of .13% per year and were of significantly lower stage. Metachronous cancers adversely impacted survival for patients with low-stage initial cancers, but the interval between cancers was less than 36 months. Synchronous tumors occurred in 2.3% of patients; survival was worse than for patients with metachronous cancers. Conclusions: Prophylactic mastectomy is unlikely to be beneficial because of the lower stages and low incidence of second cancers, even for patients with initial low-stage cancers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 645-650 |
| Number of pages | 6 |
| Journal | American Journal of Surgery |
| Volume | 195 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2008 |
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Keywords
- Breast cancer
- Contralateral
- Metachronous
- Synchronous
ASJC Scopus subject areas
- Surgery
Cite this
Incidence and outcomes of contralateral breast cancers. / Quan, Glenda; Pommier, Su Ellen Johnson; Pommier, Rodney.
In: American Journal of Surgery, Vol. 195, No. 5, 05.2008, p. 645-650.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence and outcomes of contralateral breast cancers
AU - Quan, Glenda
AU - Pommier, Su Ellen Johnson
AU - Pommier, Rodney
PY - 2008/5
Y1 - 2008/5
N2 - Background: The significance of a contralateral breast cancer is largely unknown, making prophylactic mastectomy controversial. Methods: Differences between stages of initial and contralateral cancers were determined by t test. Survival distributions were compared by log-rank analyses and compared with Surveillance Epidemiology and End Results data for unilateral cancers. Results: Metachronous contralateral cancers occurred at a rate of .13% per year and were of significantly lower stage. Metachronous cancers adversely impacted survival for patients with low-stage initial cancers, but the interval between cancers was less than 36 months. Synchronous tumors occurred in 2.3% of patients; survival was worse than for patients with metachronous cancers. Conclusions: Prophylactic mastectomy is unlikely to be beneficial because of the lower stages and low incidence of second cancers, even for patients with initial low-stage cancers.
AB - Background: The significance of a contralateral breast cancer is largely unknown, making prophylactic mastectomy controversial. Methods: Differences between stages of initial and contralateral cancers were determined by t test. Survival distributions were compared by log-rank analyses and compared with Surveillance Epidemiology and End Results data for unilateral cancers. Results: Metachronous contralateral cancers occurred at a rate of .13% per year and were of significantly lower stage. Metachronous cancers adversely impacted survival for patients with low-stage initial cancers, but the interval between cancers was less than 36 months. Synchronous tumors occurred in 2.3% of patients; survival was worse than for patients with metachronous cancers. Conclusions: Prophylactic mastectomy is unlikely to be beneficial because of the lower stages and low incidence of second cancers, even for patients with initial low-stage cancers.
KW - Breast cancer
KW - Contralateral
KW - Metachronous
KW - Synchronous
UR - http://www.scopus.com/inward/record.url?scp=42049102783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42049102783&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2008.01.007
DO - 10.1016/j.amjsurg.2008.01.007
M3 - Article
C2 - 18424281
AN - SCOPUS:42049102783
VL - 195
SP - 645
EP - 650
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 5
ER -