Inbred strain differences in morphine-induced analgesia with the hot plate assay: A reassessment

John Belknap, M. Lamé, P. W. Danielson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Using the hot plate assay of analgesia, several investigators have reported DBA/2J mice to be much more sensitive to morphine and other opioids than C57BL/6J mice using paw-lick as the behavioral end point. In the present studies, we compared DBA/2J, C57BL/6J, and C3H/HeJ mice on two behavioral end points, either (1) the initial response to the hot plate, either a hind paw-lift, paw-shake, or paw-lick, whichever occurred first, or (2) the paw-lick response. In response to either morphine or saline, all three strains showed roughly equivalent latencies to the initial response, but the DBA/2J strain was markedly slow to show paw-lick as a nocifensive response compared to the C57BL/6J strain. As a result, only for the paw-lick response were there significant differences among the three inbred strains in morphine analgesia. Thus, differences in analgesic sensitivity among these strains are largely a function of the behavioral end point used to assess nociception to the hot plate.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalBehavior Genetics
Volume20
Issue number2
DOIs
StatePublished - Mar 1990
Externally publishedYes

Fingerprint

morphine
strain differences
analgesia
Analgesia
Morphine
assay
assays
Inbred DBA Mouse
Nociception
Inbred C3H Mouse
mice
Inbred C57BL Mouse
Opioid Analgesics
Analgesics
nociception
Research Personnel
narcotics
analgesics

Keywords

  • analgesia
  • C3H/HeJ
  • C57BL/6J
  • DBA/2J
  • genetics
  • hot plate assay
  • morphine
  • opioid

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

Inbred strain differences in morphine-induced analgesia with the hot plate assay : A reassessment. / Belknap, John; Lamé, M.; Danielson, P. W.

In: Behavior Genetics, Vol. 20, No. 2, 03.1990, p. 333-338.

Research output: Contribution to journalArticle

Belknap, John ; Lamé, M. ; Danielson, P. W. / Inbred strain differences in morphine-induced analgesia with the hot plate assay : A reassessment. In: Behavior Genetics. 1990 ; Vol. 20, No. 2. pp. 333-338.
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