In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance

Tuqiang Xie, Gangjun Liu, Kelly Kreuter, Sari Mahon, Henri Colt, David Mukai, George M. Peavy, Zhongping Chen, Matthew Brenner

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The purpose of this study was to develop a dynamic tunable focal distance graded-refractive-index lens rod-based high-speed 3-D swept-source (SS) optical coherence tomography (OCT) endoscopic system and demonstrate real-time in vivo, high-resolution (10-μm) imaging of pleural-based malignancies in an animal model. The GRIN lens-based 3-D SS OCT system, which images at 39 fps with 512 A-lines per frame, was able to capture images of and detect abnormalities during thoracoscopy in the thoracic cavity, including the pleura, chest wall, pericardium, and the lungs. The abnormalities were confirmed by histological evaluation and compared to OCT findings. The dynamic tunable focal distance range and rapid speed of the probe and SS prototype OCT system enabled this first-reported application of in vivo 3-D thoracoscopic imaging of pleural-based malignancies. The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations.

Original languageEnglish (US)
Article number064045
JournalJournal of Biomedical Optics
Volume14
Issue number6
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Optical tomography
rabbits
Tumors
tumors
tomography
Tissue
Imaging techniques
cavities
abnormalities
Lenses
pleurae
lenses
gradient index optics
animal models
probes
chest
lungs
Refractive index
Animals
rods

Keywords

  • Endoscopic imaging
  • Gradient-index lenses
  • Imaging system
  • Medical and biological imaging
  • Optical coherence tomography
  • Thoracoscopic imaging
  • Thoracoscopy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance. / Xie, Tuqiang; Liu, Gangjun; Kreuter, Kelly; Mahon, Sari; Colt, Henri; Mukai, David; Peavy, George M.; Chen, Zhongping; Brenner, Matthew.

In: Journal of Biomedical Optics, Vol. 14, No. 6, 064045, 2009.

Research output: Contribution to journalArticle

Xie, Tuqiang ; Liu, Gangjun ; Kreuter, Kelly ; Mahon, Sari ; Colt, Henri ; Mukai, David ; Peavy, George M. ; Chen, Zhongping ; Brenner, Matthew. / In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance. In: Journal of Biomedical Optics. 2009 ; Vol. 14, No. 6.
@article{46c65c257fdd4530801929a71fa91fc4,
title = "In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance",
abstract = "The purpose of this study was to develop a dynamic tunable focal distance graded-refractive-index lens rod-based high-speed 3-D swept-source (SS) optical coherence tomography (OCT) endoscopic system and demonstrate real-time in vivo, high-resolution (10-μm) imaging of pleural-based malignancies in an animal model. The GRIN lens-based 3-D SS OCT system, which images at 39 fps with 512 A-lines per frame, was able to capture images of and detect abnormalities during thoracoscopy in the thoracic cavity, including the pleura, chest wall, pericardium, and the lungs. The abnormalities were confirmed by histological evaluation and compared to OCT findings. The dynamic tunable focal distance range and rapid speed of the probe and SS prototype OCT system enabled this first-reported application of in vivo 3-D thoracoscopic imaging of pleural-based malignancies. The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations.",
keywords = "Endoscopic imaging, Gradient-index lenses, Imaging system, Medical and biological imaging, Optical coherence tomography, Thoracoscopic imaging, Thoracoscopy",
author = "Tuqiang Xie and Gangjun Liu and Kelly Kreuter and Sari Mahon and Henri Colt and David Mukai and Peavy, {George M.} and Zhongping Chen and Matthew Brenner",
year = "2009",
doi = "10.1117/1.3275478",
language = "English (US)",
volume = "14",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "6",

}

TY - JOUR

T1 - In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance

AU - Xie, Tuqiang

AU - Liu, Gangjun

AU - Kreuter, Kelly

AU - Mahon, Sari

AU - Colt, Henri

AU - Mukai, David

AU - Peavy, George M.

AU - Chen, Zhongping

AU - Brenner, Matthew

PY - 2009

Y1 - 2009

N2 - The purpose of this study was to develop a dynamic tunable focal distance graded-refractive-index lens rod-based high-speed 3-D swept-source (SS) optical coherence tomography (OCT) endoscopic system and demonstrate real-time in vivo, high-resolution (10-μm) imaging of pleural-based malignancies in an animal model. The GRIN lens-based 3-D SS OCT system, which images at 39 fps with 512 A-lines per frame, was able to capture images of and detect abnormalities during thoracoscopy in the thoracic cavity, including the pleura, chest wall, pericardium, and the lungs. The abnormalities were confirmed by histological evaluation and compared to OCT findings. The dynamic tunable focal distance range and rapid speed of the probe and SS prototype OCT system enabled this first-reported application of in vivo 3-D thoracoscopic imaging of pleural-based malignancies. The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations.

AB - The purpose of this study was to develop a dynamic tunable focal distance graded-refractive-index lens rod-based high-speed 3-D swept-source (SS) optical coherence tomography (OCT) endoscopic system and demonstrate real-time in vivo, high-resolution (10-μm) imaging of pleural-based malignancies in an animal model. The GRIN lens-based 3-D SS OCT system, which images at 39 fps with 512 A-lines per frame, was able to capture images of and detect abnormalities during thoracoscopy in the thoracic cavity, including the pleura, chest wall, pericardium, and the lungs. The abnormalities were confirmed by histological evaluation and compared to OCT findings. The dynamic tunable focal distance range and rapid speed of the probe and SS prototype OCT system enabled this first-reported application of in vivo 3-D thoracoscopic imaging of pleural-based malignancies. The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations.

KW - Endoscopic imaging

KW - Gradient-index lenses

KW - Imaging system

KW - Medical and biological imaging

KW - Optical coherence tomography

KW - Thoracoscopic imaging

KW - Thoracoscopy

UR - http://www.scopus.com/inward/record.url?scp=77950349126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950349126&partnerID=8YFLogxK

U2 - 10.1117/1.3275478

DO - 10.1117/1.3275478

M3 - Article

C2 - 20059283

AN - SCOPUS:77950349126

VL - 14

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 6

M1 - 064045

ER -