In vivo three-dimensional doppler variance imaging of tumor angiogenesis on chorioallantoic membrane

Wenjuan Qi, Gangjun Liu, Zhongping Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Non-invasive tumor microvasculature visualization and characterization play significant roles in the detection of tumors and importantly, for aiding in the development of therapeutic strategies. The feasibility and effectiveness of a Doppler variance standard deviation imaging method for tumor angiogenesis on chorioallantoic membrane were tested in vivo on a rat glioma F98 tumor spheroid. Utilizing a high resolution Doppler Variance Optical Coherence Tomography (DVOCT) system with A-line rate of 20 kHz, three-dimensional mapping of a tumor with a total area of 3×2.5mm2 was completed within 15 seconds. The top-view image clearly visualized the complex vascular perfusion with the detection of capillaries as small as approximately 10μm. The results of the current study demonstrate the capability of the Doppler variance standard deviation imaging method as a non-invasive assessment of tumor angiogenesis, with the potential for its use in clinical settings.

Original languageEnglish (US)
Title of host publicationDynamics and Fluctuations in Biomedical Photonics VIII
DOIs
StatePublished - Apr 14 2011
EventDynamics and Fluctuations in Biomedical Photonics VIII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7898
ISSN (Print)1605-7422

Other

OtherDynamics and Fluctuations in Biomedical Photonics VIII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Keywords

  • Angiogenesis
  • Doppler variance
  • Microvasculature
  • Optical Coherence Tomography
  • Standard deviation
  • Tumor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'In vivo three-dimensional doppler variance imaging of tumor angiogenesis on chorioallantoic membrane'. Together they form a unique fingerprint.

Cite this