In vivo 1H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: Technical challenges

Dong Hyun Kim, Kiarash Vahidi, Aaron Caughey, Fergus Coakley, Daniel B. Vigneron, John Kurhanewicz, Ben Mow, Bonnie N. Joe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To identify the major technical challenges associated with in utero single-voxel proton spectroscopy of amniotic fluid and fetal lung and to evaluate the feasibility of performing in utero fetal spectroscopy for fetal lung maturity testing. Materials and Methods: Fetal magnetic resonance (MR) spectroscopy of amniotic fluid and fetal lung were performed at 1.5 T in 8 near-term pregnant women. Presence/absence of lactate and choline peaks was tabulated. Ex vivo spectra were obtained from amniotic fluid samples to investigate and refine sequence parameters. Results: Spectroscopy failed in 3 of 8 cases due to maternal discomfort (n = 1) or fetal gastroschisis (n = 2). Both fetal motion and low signal-to-noise ratio were limiting factors for the remaining 5 clinical in vivo studies at 1.5 T. Ex vivo and in vivo studies suggested feasibility for detecting lactate from amniotic fluid within a reasonable clinical scan time (4-5 minutes). Lactate was detected in 3 of 5 patients. Choline detection was limited and was detected in 1 patient. Conclusion: Minor motion effects can be overcome but continuous fetal motion is problematic. Lactate detection seems clinically feasible; but choline detection requires additional technical development and, potentially, further imaging at a higher field strength because of the low signal-to-noise ratio at 1.5 T.

Original languageEnglish (US)
Pages (from-to)1033-1038
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume28
Issue number4
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Amniotic Fluid
Lactic Acid
Magnetic Resonance Spectroscopy
Choline
Spectrum Analysis
Lung
Signal-To-Noise Ratio
Gastroschisis
Feasibility Studies
Protons
Pregnant Women
Mothers

Keywords

  • Amniotic fluid spectroscopy
  • Fetal imaging
  • Fetal lung spectroscopy
  • Lung maturity
  • Respiratory distress syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

In vivo 1H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T : Technical challenges. / Kim, Dong Hyun; Vahidi, Kiarash; Caughey, Aaron; Coakley, Fergus; Vigneron, Daniel B.; Kurhanewicz, John; Mow, Ben; Joe, Bonnie N.

In: Journal of Magnetic Resonance Imaging, Vol. 28, No. 4, 10.2008, p. 1033-1038.

Research output: Contribution to journalArticle

Kim, Dong Hyun ; Vahidi, Kiarash ; Caughey, Aaron ; Coakley, Fergus ; Vigneron, Daniel B. ; Kurhanewicz, John ; Mow, Ben ; Joe, Bonnie N. / In vivo 1H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T : Technical challenges. In: Journal of Magnetic Resonance Imaging. 2008 ; Vol. 28, No. 4. pp. 1033-1038.
@article{7fa88b6f62e849d68ed3d3ea6e4162da,
title = "In vivo 1H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: Technical challenges",
abstract = "Purpose: To identify the major technical challenges associated with in utero single-voxel proton spectroscopy of amniotic fluid and fetal lung and to evaluate the feasibility of performing in utero fetal spectroscopy for fetal lung maturity testing. Materials and Methods: Fetal magnetic resonance (MR) spectroscopy of amniotic fluid and fetal lung were performed at 1.5 T in 8 near-term pregnant women. Presence/absence of lactate and choline peaks was tabulated. Ex vivo spectra were obtained from amniotic fluid samples to investigate and refine sequence parameters. Results: Spectroscopy failed in 3 of 8 cases due to maternal discomfort (n = 1) or fetal gastroschisis (n = 2). Both fetal motion and low signal-to-noise ratio were limiting factors for the remaining 5 clinical in vivo studies at 1.5 T. Ex vivo and in vivo studies suggested feasibility for detecting lactate from amniotic fluid within a reasonable clinical scan time (4-5 minutes). Lactate was detected in 3 of 5 patients. Choline detection was limited and was detected in 1 patient. Conclusion: Minor motion effects can be overcome but continuous fetal motion is problematic. Lactate detection seems clinically feasible; but choline detection requires additional technical development and, potentially, further imaging at a higher field strength because of the low signal-to-noise ratio at 1.5 T.",
keywords = "Amniotic fluid spectroscopy, Fetal imaging, Fetal lung spectroscopy, Lung maturity, Respiratory distress syndrome",
author = "Kim, {Dong Hyun} and Kiarash Vahidi and Aaron Caughey and Fergus Coakley and Vigneron, {Daniel B.} and John Kurhanewicz and Ben Mow and Joe, {Bonnie N.}",
year = "2008",
month = "10",
doi = "10.1002/jmri.21528",
language = "English (US)",
volume = "28",
pages = "1033--1038",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - In vivo 1H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T

T2 - Technical challenges

AU - Kim, Dong Hyun

AU - Vahidi, Kiarash

AU - Caughey, Aaron

AU - Coakley, Fergus

AU - Vigneron, Daniel B.

AU - Kurhanewicz, John

AU - Mow, Ben

AU - Joe, Bonnie N.

PY - 2008/10

Y1 - 2008/10

N2 - Purpose: To identify the major technical challenges associated with in utero single-voxel proton spectroscopy of amniotic fluid and fetal lung and to evaluate the feasibility of performing in utero fetal spectroscopy for fetal lung maturity testing. Materials and Methods: Fetal magnetic resonance (MR) spectroscopy of amniotic fluid and fetal lung were performed at 1.5 T in 8 near-term pregnant women. Presence/absence of lactate and choline peaks was tabulated. Ex vivo spectra were obtained from amniotic fluid samples to investigate and refine sequence parameters. Results: Spectroscopy failed in 3 of 8 cases due to maternal discomfort (n = 1) or fetal gastroschisis (n = 2). Both fetal motion and low signal-to-noise ratio were limiting factors for the remaining 5 clinical in vivo studies at 1.5 T. Ex vivo and in vivo studies suggested feasibility for detecting lactate from amniotic fluid within a reasonable clinical scan time (4-5 minutes). Lactate was detected in 3 of 5 patients. Choline detection was limited and was detected in 1 patient. Conclusion: Minor motion effects can be overcome but continuous fetal motion is problematic. Lactate detection seems clinically feasible; but choline detection requires additional technical development and, potentially, further imaging at a higher field strength because of the low signal-to-noise ratio at 1.5 T.

AB - Purpose: To identify the major technical challenges associated with in utero single-voxel proton spectroscopy of amniotic fluid and fetal lung and to evaluate the feasibility of performing in utero fetal spectroscopy for fetal lung maturity testing. Materials and Methods: Fetal magnetic resonance (MR) spectroscopy of amniotic fluid and fetal lung were performed at 1.5 T in 8 near-term pregnant women. Presence/absence of lactate and choline peaks was tabulated. Ex vivo spectra were obtained from amniotic fluid samples to investigate and refine sequence parameters. Results: Spectroscopy failed in 3 of 8 cases due to maternal discomfort (n = 1) or fetal gastroschisis (n = 2). Both fetal motion and low signal-to-noise ratio were limiting factors for the remaining 5 clinical in vivo studies at 1.5 T. Ex vivo and in vivo studies suggested feasibility for detecting lactate from amniotic fluid within a reasonable clinical scan time (4-5 minutes). Lactate was detected in 3 of 5 patients. Choline detection was limited and was detected in 1 patient. Conclusion: Minor motion effects can be overcome but continuous fetal motion is problematic. Lactate detection seems clinically feasible; but choline detection requires additional technical development and, potentially, further imaging at a higher field strength because of the low signal-to-noise ratio at 1.5 T.

KW - Amniotic fluid spectroscopy

KW - Fetal imaging

KW - Fetal lung spectroscopy

KW - Lung maturity

KW - Respiratory distress syndrome

UR - http://www.scopus.com/inward/record.url?scp=53549111616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53549111616&partnerID=8YFLogxK

U2 - 10.1002/jmri.21528

DO - 10.1002/jmri.21528

M3 - Article

C2 - 18821604

AN - SCOPUS:53549111616

VL - 28

SP - 1033

EP - 1038

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 4

ER -