In vivo outer hair cell length changes expose the active process in the cochlea

Dingjun Zha, Fangyi Chen, Sripriya Ramamoorthy, Anders Fridberger, Niloy Choudhury, Steven Jacques, Ruikang K. Wang, Alfred Nuttall

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required that the outer hair cells dynamically change their length, in addition to generating force. These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification. Methodology/Principal Findings: Using in vivo optical coherence tomography, we demonstrate that outer hair cells in living guinea pigs have length changes with unexpected timing and magnitudes that depend on the stimulus level in the sensitive cochlea. Conclusions/Significance: The level-dependent length change is a necessary condition for directly validating that power is expended by the active process presumed to underlie normal hearing.

Original languageEnglish (US)
Article numbere32757
JournalPLoS One
Volume7
Issue number4
DOIs
StatePublished - Apr 9 2012

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Outer Auditory Hair Cells
Cochlea
hairs
Amplification
Cells
Audition
Hearing
hearing
Optical tomography
Optical Coherence Tomography
cells
Vibration
Acoustics
Vibrations (mechanical)
tomography
Guinea Pigs
vibration
Acoustic waves
guinea pigs
acoustics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zha, D., Chen, F., Ramamoorthy, S., Fridberger, A., Choudhury, N., Jacques, S., ... Nuttall, A. (2012). In vivo outer hair cell length changes expose the active process in the cochlea. PLoS One, 7(4), [e32757]. https://doi.org/10.1371/journal.pone.0032757

In vivo outer hair cell length changes expose the active process in the cochlea. / Zha, Dingjun; Chen, Fangyi; Ramamoorthy, Sripriya; Fridberger, Anders; Choudhury, Niloy; Jacques, Steven; Wang, Ruikang K.; Nuttall, Alfred.

In: PLoS One, Vol. 7, No. 4, e32757, 09.04.2012.

Research output: Contribution to journalArticle

Zha, D, Chen, F, Ramamoorthy, S, Fridberger, A, Choudhury, N, Jacques, S, Wang, RK & Nuttall, A 2012, 'In vivo outer hair cell length changes expose the active process in the cochlea', PLoS One, vol. 7, no. 4, e32757. https://doi.org/10.1371/journal.pone.0032757
Zha D, Chen F, Ramamoorthy S, Fridberger A, Choudhury N, Jacques S et al. In vivo outer hair cell length changes expose the active process in the cochlea. PLoS One. 2012 Apr 9;7(4). e32757. https://doi.org/10.1371/journal.pone.0032757
Zha, Dingjun ; Chen, Fangyi ; Ramamoorthy, Sripriya ; Fridberger, Anders ; Choudhury, Niloy ; Jacques, Steven ; Wang, Ruikang K. ; Nuttall, Alfred. / In vivo outer hair cell length changes expose the active process in the cochlea. In: PLoS One. 2012 ; Vol. 7, No. 4.
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