In-vivo NMR thermometry with liposomes containing 59co complexes

A. G. Webb, M. Wong, M. Niesman, Kenneth Kolbeck, L. J. Wilmess, R. L. Magin, K. S. Suslick

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of its 59Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 °C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalInternational Journal of Hyperthermia
Volume11
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Thermometry
Liposomes
Temperature
Mononuclear Phagocyte System
Half-Life
Spectrum Analysis
Fever
Magnetic Resonance Spectroscopy
Neoplasms

Keywords

  • Coblat
  • Liposomes
  • NMR
  • Thermometry

ASJC Scopus subject areas

  • Cancer Research
  • Physiology
  • Radiological and Ultrasound Technology
  • Physiology (medical)

Cite this

Webb, A. G., Wong, M., Niesman, M., Kolbeck, K., Wilmess, L. J., Magin, R. L., & Suslick, K. S. (1995). In-vivo NMR thermometry with liposomes containing 59co complexes. International Journal of Hyperthermia, 11(6), 821-827. https://doi.org/10.3109/02656739509052338

In-vivo NMR thermometry with liposomes containing 59co complexes. / Webb, A. G.; Wong, M.; Niesman, M.; Kolbeck, Kenneth; Wilmess, L. J.; Magin, R. L.; Suslick, K. S.

In: International Journal of Hyperthermia, Vol. 11, No. 6, 1995, p. 821-827.

Research output: Contribution to journalArticle

Webb, AG, Wong, M, Niesman, M, Kolbeck, K, Wilmess, LJ, Magin, RL & Suslick, KS 1995, 'In-vivo NMR thermometry with liposomes containing 59co complexes', International Journal of Hyperthermia, vol. 11, no. 6, pp. 821-827. https://doi.org/10.3109/02656739509052338
Webb, A. G. ; Wong, M. ; Niesman, M. ; Kolbeck, Kenneth ; Wilmess, L. J. ; Magin, R. L. ; Suslick, K. S. / In-vivo NMR thermometry with liposomes containing 59co complexes. In: International Journal of Hyperthermia. 1995 ; Vol. 11, No. 6. pp. 821-827.
@article{bc9f30573121465ab278f4553337491b,
title = "In-vivo NMR thermometry with liposomes containing 59co complexes",
abstract = "The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of its 59Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 °C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.",
keywords = "Coblat, Liposomes, NMR, Thermometry",
author = "Webb, {A. G.} and M. Wong and M. Niesman and Kenneth Kolbeck and Wilmess, {L. J.} and Magin, {R. L.} and Suslick, {K. S.}",
year = "1995",
doi = "10.3109/02656739509052338",
language = "English (US)",
volume = "11",
pages = "821--827",
journal = "International Journal of Hyperthermia",
issn = "0265-6736",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - In-vivo NMR thermometry with liposomes containing 59co complexes

AU - Webb, A. G.

AU - Wong, M.

AU - Niesman, M.

AU - Kolbeck, Kenneth

AU - Wilmess, L. J.

AU - Magin, R. L.

AU - Suslick, K. S.

PY - 1995

Y1 - 1995

N2 - The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of its 59Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 °C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.

AB - The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of its 59Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 °C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.

KW - Coblat

KW - Liposomes

KW - NMR

KW - Thermometry

UR - http://www.scopus.com/inward/record.url?scp=0028844677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028844677&partnerID=8YFLogxK

U2 - 10.3109/02656739509052338

DO - 10.3109/02656739509052338

M3 - Article

VL - 11

SP - 821

EP - 827

JO - International Journal of Hyperthermia

JF - International Journal of Hyperthermia

SN - 0265-6736

IS - 6

ER -