In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography

Comparison with radiolabeled red blood cells

Ananda R. Jayaweera, Nathaniel Edwards, William P. Glasheen, Flordeliza S. Villanueva, Robert D. Abbott, Sanjiv Kaul

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3±0.3 μm and an intravascular rheology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provide an estimation of regional myocardial blood flow in the in vivo beating heart. Accordingly, blood flow to the left anterior descending coronary artery (LAD) of 12 open-chest anesthetized dogs (group I) was adjusted to 4 to 6 flows (total of 60 flows), and microbubbles and radiolabeled RBCs were injected into the LAD in a random order at each stage. The mean myocardial RBC transit rates were measured by fitting a gamma-variate function to time-activity plots generated by placing a miniature CsI2 probe over the anterior surface of the heart, and the mean myocardial microbubble transit rates were measured from time-intensity plots derived from off-line analysis of MCE images obtained during the injection of microbubbles. An excellent correlation was noted between flow (measured with an extracorporeal electromagnetic flow probe) and mean myocardial RBC transit rate (y = 2.83 x 10-3x + 0.01, r = .96, SEE = 0.02, P

Original languageEnglish (US)
Pages (from-to)1157-1165
Number of pages9
JournalCirculation Research
Volume74
Issue number6
StatePublished - Jun 1994
Externally publishedYes

Fingerprint

Microbubbles
Echocardiography
Albumins
Erythrocytes
Air
Injections
Rheology
Electromagnetic Phenomena
Regional Blood Flow
Coronary Vessels
Thorax
Perfusion
Dogs

Keywords

  • myocardial contrast echocardiography
  • red blood cells

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography : Comparison with radiolabeled red blood cells. / Jayaweera, Ananda R.; Edwards, Nathaniel; Glasheen, William P.; Villanueva, Flordeliza S.; Abbott, Robert D.; Kaul, Sanjiv.

In: Circulation Research, Vol. 74, No. 6, 06.1994, p. 1157-1165.

Research output: Contribution to journalArticle

Jayaweera, Ananda R. ; Edwards, Nathaniel ; Glasheen, William P. ; Villanueva, Flordeliza S. ; Abbott, Robert D. ; Kaul, Sanjiv. / In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography : Comparison with radiolabeled red blood cells. In: Circulation Research. 1994 ; Vol. 74, No. 6. pp. 1157-1165.
@article{53d3f9c5399f4669b82f121d616ebc37,
title = "In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: Comparison with radiolabeled red blood cells",
abstract = "Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3±0.3 μm and an intravascular rheology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provide an estimation of regional myocardial blood flow in the in vivo beating heart. Accordingly, blood flow to the left anterior descending coronary artery (LAD) of 12 open-chest anesthetized dogs (group I) was adjusted to 4 to 6 flows (total of 60 flows), and microbubbles and radiolabeled RBCs were injected into the LAD in a random order at each stage. The mean myocardial RBC transit rates were measured by fitting a gamma-variate function to time-activity plots generated by placing a miniature CsI2 probe over the anterior surface of the heart, and the mean myocardial microbubble transit rates were measured from time-intensity plots derived from off-line analysis of MCE images obtained during the injection of microbubbles. An excellent correlation was noted between flow (measured with an extracorporeal electromagnetic flow probe) and mean myocardial RBC transit rate (y = 2.83 x 10-3x + 0.01, r = .96, SEE = 0.02, P",
keywords = "myocardial contrast echocardiography, red blood cells",
author = "Jayaweera, {Ananda R.} and Nathaniel Edwards and Glasheen, {William P.} and Villanueva, {Flordeliza S.} and Abbott, {Robert D.} and Sanjiv Kaul",
year = "1994",
month = "6",
language = "English (US)",
volume = "74",
pages = "1157--1165",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography

T2 - Comparison with radiolabeled red blood cells

AU - Jayaweera, Ananda R.

AU - Edwards, Nathaniel

AU - Glasheen, William P.

AU - Villanueva, Flordeliza S.

AU - Abbott, Robert D.

AU - Kaul, Sanjiv

PY - 1994/6

Y1 - 1994/6

N2 - Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3±0.3 μm and an intravascular rheology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provide an estimation of regional myocardial blood flow in the in vivo beating heart. Accordingly, blood flow to the left anterior descending coronary artery (LAD) of 12 open-chest anesthetized dogs (group I) was adjusted to 4 to 6 flows (total of 60 flows), and microbubbles and radiolabeled RBCs were injected into the LAD in a random order at each stage. The mean myocardial RBC transit rates were measured by fitting a gamma-variate function to time-activity plots generated by placing a miniature CsI2 probe over the anterior surface of the heart, and the mean myocardial microbubble transit rates were measured from time-intensity plots derived from off-line analysis of MCE images obtained during the injection of microbubbles. An excellent correlation was noted between flow (measured with an extracorporeal electromagnetic flow probe) and mean myocardial RBC transit rate (y = 2.83 x 10-3x + 0.01, r = .96, SEE = 0.02, P

AB - Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3±0.3 μm and an intravascular rheology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provide an estimation of regional myocardial blood flow in the in vivo beating heart. Accordingly, blood flow to the left anterior descending coronary artery (LAD) of 12 open-chest anesthetized dogs (group I) was adjusted to 4 to 6 flows (total of 60 flows), and microbubbles and radiolabeled RBCs were injected into the LAD in a random order at each stage. The mean myocardial RBC transit rates were measured by fitting a gamma-variate function to time-activity plots generated by placing a miniature CsI2 probe over the anterior surface of the heart, and the mean myocardial microbubble transit rates were measured from time-intensity plots derived from off-line analysis of MCE images obtained during the injection of microbubbles. An excellent correlation was noted between flow (measured with an extracorporeal electromagnetic flow probe) and mean myocardial RBC transit rate (y = 2.83 x 10-3x + 0.01, r = .96, SEE = 0.02, P

KW - myocardial contrast echocardiography

KW - red blood cells

UR - http://www.scopus.com/inward/record.url?scp=0028308410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028308410&partnerID=8YFLogxK

M3 - Article

VL - 74

SP - 1157

EP - 1165

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 6

ER -