In vivo migration and function of transferred HIV-1-specific cytotoxic T cells

Scott J. Brodie, Deborah A. Lewinsohn, Bruce K. Patterson, Daniel Jiyamapa, John Krieger, Lawrence Corey, Philip D. Greenberg, Stanley R. Riddell

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278 Scopus citations

Abstract

The persistence of HIV replication in infected individuals may reflect an inadequate host HIV-specific CD8+ cytotoxic T lymphocyte (CTL) response. The functional activity of HIV-specific CTLs and the ability of these effector cells to migrate in vivo to sites of infection was directly assessed by expanding autologous HIV-1 Gag-specific CD8+ CTL clones in vitro and adoptively transferring these CTLs to HIV-infected individuals. The transferred CTLs retained lytic function in vivo, accumulated adjacent to HIV-infected cells in lymph nodes and transiently reduced the levels of circulating productively infected CD4+ T cells. These results provide direct evidence that HIV-specific CTLs target sites of HIV replication and mediate antiviral activity, and indicate that the development of immunotherapeutic approaches to sustain a strong CTL response to HIV may be a useful adjunct to treatment of HIV infection.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalNature medicine
Volume5
Issue number1
DOIs
StatePublished - Feb 2 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Brodie, S. J., Lewinsohn, D. A., Patterson, B. K., Jiyamapa, D., Krieger, J., Corey, L., Greenberg, P. D., & Riddell, S. R. (1999). In vivo migration and function of transferred HIV-1-specific cytotoxic T cells. Nature medicine, 5(1), 34-41. https://doi.org/10.1038/4716