In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system

Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng, Niloy Choudhury, Steven Jacques, Ruikang K. Wange, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The differential motion of the organ of Corti has been expected as a result of the outer hair cell force, believed to be necessary for the cochlear amplifier. In vitro experiments have been performed to demonstrate this motion but the in vivo data was unavailable due to the technical difficulties. Using a specially-designed time-domain optical coherence tomography system, we performed in vivo imaging and vibration measurement at the sensitive base of the guinea pig cochlea. This technique, for the first time, provides in vivo information about the internal vibration of the organ of Corti. At low sound level, when the cochlea is more sensitive, top surface of the organ of Corti, the reticular lamina (RL) showed tuning at a higher frequency than of the bottom surface, basilar membrane (BM) and its vibration amplitude is 2-3 times of that of the BM. Corresponding to the frequency difference, the phase of RL vibration is lead to that of the BM. Both the amplitude gain and the phase lead on RL is level dependent. This suggests that they are related to the cochlear amplification. The amplitude gain at the RL is an enhancement of the BM motion for stimulating the stereocillia. The advance in time of RL vibration can prepare proper timing of stereocillia stimulation for the cochlear amplification.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
DOIs
StatePublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period1/21/121/24/12

Fingerprint

Organ of Corti
Basilar Membrane
Cochlea
Vibration
organs
Interferometers
interferometers
Membranes
membranes
cochlea
vibration
Amplification
Outer Auditory Hair Cells
Vibration measurement
Optical tomography
guinea pigs
vibration measurement
Vibrations (mechanical)
hair
Optical Coherence Tomography

Keywords

  • Cochlea
  • Low coherence interferometer
  • Organ of corti
  • Vibration

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Chen, F., Zha, D., Fridberger, A., Zheng, J., Choudhury, N., Jacques, S., ... Nuttall, A. (2012). In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8207). [820726] https://doi.org/10.1117/12.908933

In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system. / Chen, Fangyi; Zha, Dingjun; Fridberger, Anders; Zheng, Jiefu; Choudhury, Niloy; Jacques, Steven; Wange, Ruikang K.; Nuttall, Alfred.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012. 820726.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, F, Zha, D, Fridberger, A, Zheng, J, Choudhury, N, Jacques, S, Wange, RK & Nuttall, A 2012, In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8207, 820726, Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, United States, 1/21/12. https://doi.org/10.1117/12.908933
Chen F, Zha D, Fridberger A, Zheng J, Choudhury N, Jacques S et al. In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207. 2012. 820726 https://doi.org/10.1117/12.908933
Chen, Fangyi ; Zha, Dingjun ; Fridberger, Anders ; Zheng, Jiefu ; Choudhury, Niloy ; Jacques, Steven ; Wange, Ruikang K. ; Nuttall, Alfred. / In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012.
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