In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography

Niloy Choudhury, Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng, Steven Jacques, Ruikang K. Wang, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hearing in mammals, depend on an amplifying motion which hypothetically uses force from outer hair cells (OHC) motility to enhance sound induced vibration of the organ of Corti of cochlea. In this hypothesis the differential motion among key structures in this organ and the timing of the OHC force generation is essential for cochlear amplification to occur. Using a time domain optical coherence tomography system which allows us to make vibration measurements we were able to measure differential motion of two functionally important surfaces, namely, basilar membrane and reticular lamina. The reticular lamina vibrates at higher amplitude than the basilar membrane and has significant phase lead over basilar membrane vibration. The differential motion, that is, different amplitude and phase of vibration, become less as the energy of the sound stimulus is increased and the amplification processes in the organ of Corti are quenched.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8213
ISBN (Print)9780819488565
DOIs
StatePublished - 2012
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Fingerprint

Organ of Corti
Optical tomography
Optical Coherence Tomography
Basilar Membrane
Vibration
stimulation
Outer Auditory Hair Cells
organs
tomography
Acoustic waves
Membranes
Vibrations (mechanical)
Amplification
acoustics
Cochlea
hair
membranes
vibration
Vibration measurement
Mammals

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Choudhury, N., Chen, F., Zha, D., Fridberger, A., Zheng, J., Jacques, S., ... Nuttall, A. (2012). In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8213). [82131P] SPIE. https://doi.org/10.1117/12.910224

In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography. / Choudhury, Niloy; Chen, Fangyi; Zha, Dingjun; Fridberger, Anders; Zheng, Jiefu; Jacques, Steven; Wang, Ruikang K.; Nuttall, Alfred.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213 SPIE, 2012. 82131P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Choudhury, N, Chen, F, Zha, D, Fridberger, A, Zheng, J, Jacques, S, Wang, RK & Nuttall, A 2012, In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8213, 82131P, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, San Francisco, CA, United States, 1/23/12. https://doi.org/10.1117/12.910224
Choudhury N, Chen F, Zha D, Fridberger A, Zheng J, Jacques S et al. In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213. SPIE. 2012. 82131P https://doi.org/10.1117/12.910224
Choudhury, Niloy ; Chen, Fangyi ; Zha, Dingjun ; Fridberger, Anders ; Zheng, Jiefu ; Jacques, Steven ; Wang, Ruikang K. ; Nuttall, Alfred. / In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213 SPIE, 2012.
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