In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography

Niloy Choudhury, Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng, Steven L. Jacques, Ruikang K. Wang, Alfred L. Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hearing in mammals, depend on an amplifying motion which hypothetically uses force from outer hair cells (OHC) motility to enhance sound induced vibration of the organ of Corti of cochlea. In this hypothesis the differential motion among key structures in this organ and the timing of the OHC force generation is essential for cochlear amplification to occur. Using a time domain optical coherence tomography system which allows us to make vibration measurements we were able to measure differential motion of two functionally important surfaces, namely, basilar membrane and reticular lamina. The reticular lamina vibrates at higher amplitude than the basilar membrane and has significant phase lead over basilar membrane vibration. The differential motion, that is, different amplitude and phase of vibration, become less as the energy of the sound stimulus is increased and the amplification processes in the organ of Corti are quenched.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
PublisherSPIE
ISBN (Print)9780819488565
DOIs
StatePublished - Jan 1 2012
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8213
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Choudhury, N., Chen, F., Zha, D., Fridberger, A., Zheng, J., Jacques, S. L., Wang, R. K., & Nuttall, A. L. (2012). In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI [82131P] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8213). SPIE. https://doi.org/10.1117/12.910224